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Submit ReviewtcY-NH2
Description: Selective PAR4 antagonist
Alternative Names: (trans-Cinnamoyl)-YPGKF-NH2
Purity: ≥95% (HPLC)
Biological Activity for tcY-NH2
tcY-NH2 is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
Technical Data for tcY-NH2
| M. Wt | 739.87 |
| Formula | C40H49N7O7 |
| Sequence |
YPGKF (Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 327177-34-4 |
| PubChem ID | 11479675 |
| InChI Key | XKRAKQXQVIGYQC-PHOSSJRVSA-N |
| Smiles | NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for tcY-NH2
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for tcY-NH2
References for tcY-NH2
References are publications that support the biological activity of the product.
Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701 PMID: 11606309
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Keywords: tcY-NH2, tcY-NH2 supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, (trans-Cinnamoyl)-YPGKF-NH2, 1488, Tocris Bioscience
4 Citations for tcY-NH2
Citations are publications that use Tocris products. Selected citations for tcY-NH2 include:
Chen et al (2022) Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor. Cell Death Discov. 8 189 PMID: 35399122
Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Redox Biol 34 346 PMID: 24469043
Carrim et al (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Br J Cancer 6 640 PMID: 26569550
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Do you know of a great paper that uses tcY-NH2 from Tocris? Please let us know.
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