tcY-NH2

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Cat.No. 1488 - tcY-NH2 | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-NH2 | CAS No. 327177-34-4
Description: Selective PAR4 antagonist
Alternative Names: (trans-Cinnamoyl)-YPGKF-NH2
Datasheet
Citations (2)
Literature

Biological Activity

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Technical Data

M. Wt 739.87
Formula C40H49N7O7
Sequence YPGKF

(Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 327177-34-4
PubChem ID 11479675
InChI Key XKRAKQXQVIGYQC-PHOSSJRVSA-N
Smiles NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 739.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.35 mL 6.76 mL 13.52 mL
5 mM 0.27 mL 1.35 mL 2.7 mL
10 mM 0.14 mL 0.68 mL 1.35 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248

Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701 PMID: 11606309


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Keywords: tcY-NH2, supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, (trans-Cinnamoyl)-YPGKF-NH2, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience

2 Citations for tcY-NH2

Citations are publications that use Tocris products. Selected citations for tcY-NH2 include:

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Redox Biol 34 346 PMID: 24469043

Carrim et al (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb╬▒. Br J Cancer 6 640 PMID: 26569550


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Literature in this Area

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Pathways for tcY-NH2

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