Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
(Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701 PMID: 11606309
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Keywords: tcY-NH2, tcY-NH2 supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, (trans-Cinnamoyl)-YPGKF-NH2, 1488, Tocris Bioscience
3 Citations for tcY-NH2
Citations are publications that use Tocris products. Selected citations for tcY-NH2 include:
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Redox Biol 34 346 PMID: 24469043
Carrim et al (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Br J Cancer 6 640 PMID: 26569550
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