TCS 2510
Biological Activity
Highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.
Technical Data
| M. Wt | 383.49 |
| Formula | C21H29N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 346673-06-1 |
| PubChem ID | 9864831 |
| InChI Key | JWYPJSNXPZTEHL-VJKINUSGSA-N |
| Smiles | O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 383.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129 PMID:
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Keywords: TCS2510 ep4 prostanoid receptors selective agonists Prostanoid Receptors
1 Citation for TCS 2510
Citations are publications that use Tocris products. Selected citations for TCS 2510 include:
Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297
Do you know of a great paper that uses TCS 2510 from Tocris? If so please let us know.
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