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Submit ReviewTCS 2510 is a highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.
M. Wt | 383.49 |
Formula | C21H29N5O2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 346673-06-1 |
PubChem ID | 9864831 |
InChI Key | JWYPJSNXPZTEHL-VJKINUSGSA-N |
Smiles | O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
References are publications that support the biological activity of the product.
Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129
If you know of a relevant reference for TCS 2510, please let us know.
Keywords: TCS 2510, TCS 2510 supplier, TCS2510, ep4, prostanoid, receptors, selective, agonists, Prostanoid, Receptors, 4069, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TCS 2510 include:
Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.