TCS 2510

Pricing Availability   Qty
Description: Selective EP4 agonist
Chemical Name: (5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for TCS 2510

TCS 2510 is a highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.

Technical Data for TCS 2510

M. Wt 383.49
Formula C21H29N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346673-06-1
PubChem ID 9864831
Smiles O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 2510

Solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Product Datasheets for TCS 2510

Certificate of Analysis / Product Datasheet
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References for TCS 2510

References are publications that support the biological activity of the product.

Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129

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Keywords: TCS 2510, TCS 2510 supplier, TCS2510, ep4, prostanoid, receptors, selective, agonists, Prostanoid, Receptors, 4069, Tocris Bioscience

2 Citations for TCS 2510

Citations are publications that use Tocris products. Selected citations for TCS 2510 include:

Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297

Tzu-Ming et al (2020) Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis. J Pharmacol Exp Ther 375 357-366 PMID: 32848074

Do you know of a great paper that uses TCS 2510 from Tocris? Please let us know.

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