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Submit ReviewTCS 2510
Description: Selective EP4 agonist
Chemical Name: (5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone
Purity: ≥98% (HPLC)
Biological Activity
Highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.
Technical Data
| M. Wt | 383.49 |
| Formula | C21H29N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 346673-06-1 |
| PubChem ID | 9864831 |
| InChI Key | JWYPJSNXPZTEHL-VJKINUSGSA-N |
| Smiles | O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Product Datasheets
References
References are publications that support the biological activity of the product.
Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129
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Keywords: TCS 2510, TCS 2510 supplier, TCS2510, ep4, prostanoid, receptors, selective, agonists, Prostanoid, Receptors, 4069, Tocris Bioscience
1 Citation for TCS 2510
Citations are publications that use Tocris products. Selected citations for TCS 2510 include:
Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297
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Literature in this Area
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