TCS 2510
Biological Activity
Highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.
Technical Data
| M. Wt | 383.49 |
| Formula | C21H29N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 346673-06-1 |
| PubChem ID | 9864831 |
| InChI Key | JWYPJSNXPZTEHL-VJKINUSGSA-N |
| Smiles | O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 383.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129
If you know of a relevant reference for TCS 2510, please let us know.
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Keywords: TCS 2510, TCS 2510 supplier, TCS2510, ep4, prostanoid, receptors, selective, agonists, Prostanoid, Receptors, 4069, Tocris Bioscience
1 Citation for TCS 2510
Citations are publications that use Tocris products. Selected citations for TCS 2510 include:
Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297
Do you know of a great paper that uses TCS 2510 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
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A collection of over 190 products for immunology research, the guide includes research tools for the study of:
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Asthma Poster
Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
