TC-G 1004

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Cat.No. 4407 - TC-G 1004 | C22H27N7O2 | CAS No. 1061747-72-5
Description: Potent and selective A2A antagonist
Chemical Name: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.

Compound Libraries

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Technical Data

M. Wt 421.5
Formula C22H27N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1061747-72-5
PubChem ID 25074316
InChI Key JENSDTKXNVHSSN-UHFFFAOYSA-N
Smiles CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 42.15 100
DMSO 42.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 51 7099 PMID: 18947224


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Keywords: TC-G 1004, supplier, TC-G1004, adenosine, A2A, receptors, selective, potent, antagonists, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience

Citations for TC-G 1004

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Literature in this Area

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