TC-G 1003

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Cat.No. 5080 - TC-G 1003 | C26H25ClN2O2 | CAS No. 1021912-42-4
Description: High affinity somatostatin sst2 receptor agonist
Chemical Name: 3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity somatostatin sst2 receptor agonist (Ki = 0.025 nM). Inhibits growth hormone secretion and attenuates laser-induced ocular neovascular lesion size in rats.

Technical Data

M. Wt 432.94
Formula C26H25ClN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1021912-42-4
PubChem ID 52936725
InChI Key GXGVWEMSSIKHOZ-UHFFFAOYSA-N
Smiles CC1=CC(C3=C(OCCCN)C2=CC(C4=CC=CC(O)=C4)=C(Cl)C=C2N=C3)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.29 100
ethanol 43.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 432.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.55 mL 23.1 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Wolkenberg et al (2011) Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2. J.Med.Chem. 54 2351 PMID: 21395312


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Citations for TC-G 1003

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