TC-E 5003

Discontinued Product

TC-E 5003 (Cat. No. 5099) has been withdrawn from sale for commercial reasons.
Description: Selective PRMT1 inhibitor
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for TC-E 5003

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.

Technical Data for TC-E 5003

M. Wt 401.26
Formula C16H14Cl2N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 17328-16-4
PubChem ID 87052
InChI Key SHRCVZJKZJGIHQ-UHFFFAOYSA-N
Smiles O=C(CCl)NC(C=C2)=CC=C2S(C1=CC=C(NC(CCl)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC-E 5003

References are publications that support the biological activity of the product.

Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717 PMID: 21440447

View Related Products by Product Action

View all Protein Arginine Methyltransferase Inhibitors

Keywords: TC-E 5003, TC-E 5003 supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5099, Tocris Bioscience

1 Citation for TC-E 5003

Citations are publications that use Tocris products. Selected citations for TC-E 5003 include:

Min-Jung et al (2020) TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. FEBS Lett 594 2923-2930 PMID: 32767856


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.