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Biological Activity for TC-E 5003
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
Technical Data for TC-E 5003
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-E 5003
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC-E 5003
The following data is based on the product molecular weight 401.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.98 mL||24.92 mL||49.84 mL|
|2.5 mM||1 mL||4.98 mL||9.97 mL|
|5 mM||0.5 mL||2.49 mL||4.98 mL|
|25 mM||0.1 mL||0.5 mL||1 mL|
References for TC-E 5003
References are publications that support the biological activity of the product.
Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717 PMID: 21440447
If you know of a relevant reference for TC-E 5003, please let us know.
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Keywords: TC-E 5003, TC-E 5003 supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5099, Tocris Bioscience
Citations for TC-E 5003
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases