Tabimorelin hemifumarate

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Description: Potent, orally active ghrelin receptor agonist
Alternative Names: NN 703
Chemical Name: N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide hemifumarate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Tabimorelin hemifumarate

Tabimorelin hemifumarate is a potent, orally active ghrelin receptor (GHS-R1a) agonist (Ki = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC50 value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats.

Technical Data for Tabimorelin hemifumarate

M. Wt 586.73
Formula C32H40N4O3.½C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 242143-80-2
PubChem ID 11981159
Smiles [H]OC(=O)\C=C\C(=O)O[H].CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N.CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tabimorelin hemifumarate

Solvent Max Conc. mg/mL Max Conc. mM
water 5.29 10 with gentle warming
DMSO 58.67 100

Preparing Stock Solutions for Tabimorelin hemifumarate

The following data is based on the product molecular weight 586.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.52 mL 17.04 mL
5 mM 0.34 mL 1.7 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for Tabimorelin hemifumarate

References for Tabimorelin hemifumarate

References are publications that support the biological activity of the product.

Hansen et al (1999) Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur.J.Endocrinol. 141 180 PMID: 10427162

Holm et al (2004) Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Eur.J.Pharmacol. 150 893 PMID: 15191361

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Keywords: Tabimorelin hemifumarate, Tabimorelin hemifumarate supplier, Potent, orally, active, ghrelin, receptor, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, NN703, NN, 703, Ghrelin, 2308, Tocris Bioscience

Citations for Tabimorelin hemifumarate

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Literature in this Area

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.