Sulprostone

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Cat.No. 3049 - Sulprostone | C23H31NO7S | CAS No. 60325-46-4
Description: EP3 and EP1 receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective EP3 and EP1 receptor agonist (Ki values are 0.6 and 21 nM respectively). Synthetic PGE2 analog and allodynic agent.

Technical Data

M. Wt 465.56
Formula C23H31NO7S
Storage Store at -20°C
CAS Number 60325-46-4
PubChem ID 5312153
InChI Key UQZVCDCIMBLVNR-TWYODKAFSA-N
Smiles O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gil et al (2008) Transient allodynia pain models in mice for assessment of analgesic activity. Br.J.Pharmacol. 153 769 PMID: 17700719

Narumiya et al (1999) Prostanoid receptors: Structures, properties, and functions. Phys.Rev. 79 1193


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Citations for Sulprostone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

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Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.