Sulprostone

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Cat.No. 3049 - Sulprostone | C23H31NO7S | CAS No. 60325-46-4
Description: EP3 and EP1 receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
Datasheet
Citations
Literature

Biological Activity

Selective EP3 and EP1 receptor agonist (Ki values are 0.6 and 21 nM respectively). Synthetic PGE2 analog and allodynic agent.

Technical Data

M. Wt 465.56
Formula C23H31NO7S
Storage Store at -20°C
CAS Number 60325-46-4
PubChem ID 5312153
InChI Key UQZVCDCIMBLVNR-TWYODKAFSA-N
Smiles O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in methyl acetate (supplied pre-dissolved - 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 465.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gil et al (2008) Transient allodynia pain models in mice for assessment of analgesic activity. Br.J.Pharmacol. 153 769 PMID: 17700719

Narumiya et al (1999) Prostanoid receptors: Structures, properties, and functions. Phys.Rev. 79 1193 PMID:


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Keywords: Sulprostone prostaglandin prostanoid EP1 EP3 receptor agonist Prostanoid Receptors

Citations for Sulprostone

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Literature in this Area

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Pathways for Sulprostone

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