Discontinued Product

Sulprostone (Cat. No. 3049) has been withdrawn from sale for commercial reasons.
Description: EP3 and EP1 receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
Citations (1)

Biological Activity for Sulprostone

Sulprostone is a selective EP3 and EP1 receptor agonist (Ki values are 0.6 and 21 nM respectively). Synthetic PGE2 analog and allodynic agent.

Technical Data for Sulprostone

M. Wt 465.56
Formula C23H31NO7S
Storage Store at -20°C
CAS Number 60325-46-4
PubChem ID 5312153
Smiles O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Sulprostone

Certificate of Analysis / Product Datasheet
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References for Sulprostone

References are publications that support the biological activity of the product.

Gil et al (2008) Transient allodynia pain models in mice for assessment of analgesic activity. Br.J.Pharmacol. 153 769 PMID: 17700719

Narumiya et al (1999) Prostanoid receptors: Structures, properties, and functions. Phys.Rev. 79 1193

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Keywords: Sulprostone, Sulprostone supplier, Sulprostone, prostaglandin, prostanoid, EP1, EP3, receptor, agonist, Prostanoid, Receptors, 3049, Tocris Bioscience

1 Citation for Sulprostone

Citations are publications that use Tocris products. Selected citations for Sulprostone include:

Ye et al (2018) Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7 749 PMID: 29700097

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