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Description: EP3 and EP1 receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
Biological Activity for Sulprostone
Sulprostone is a selective EP3 and EP1 receptor agonist (Ki values are 0.6 and 21 nM respectively). Synthetic PGE2 analog and allodynic agent.
Technical Data for Sulprostone
| M. Wt | 465.56 |
| Formula | C23H31NO7S |
| Storage | Store at -20°C |
| CAS Number | 60325-46-4 |
| PubChem ID | 5312153 |
| InChI Key | UQZVCDCIMBLVNR-TWYODKAFSA-N |
| Smiles | O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sulprostone
| Solubility | Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml) |
Product Datasheets for Sulprostone
References for Sulprostone
References are publications that support the biological activity of the product.
Gil et al (2008) Transient allodynia pain models in mice for assessment of analgesic activity. Br.J.Pharmacol. 153 769 PMID: 17700719
Narumiya et al (1999) Prostanoid receptors: Structures, properties, and functions. Phys.Rev. 79 1193
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Keywords: Sulprostone, Sulprostone supplier, Sulprostone, prostaglandin, prostanoid, EP1, EP3, receptor, agonist, Prostanoid, Receptors, 3049, Tocris Bioscience
1 Citation for Sulprostone
Citations are publications that use Tocris products. Selected citations for Sulprostone include:
Ye et al (2018) Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7 749 PMID: 29700097
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
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Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.