Stressin I

Pricing Availability Delivery Time Qty
Cat.No. 1608 - Stressin I | Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-cyclo(γ-Glu-His-Ser-ε-Lys)-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2
Description: CRF1 agonist
Alternative Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)
Datasheet
Citations (2)
Reviews (1)
Literature

Biological Activity

Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M. Wt 4472.24
Formula C203H337N57O56
Sequence PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII

(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

Storage Desiccate at -20°C
PubChem ID 90479815
InChI Key HZKFMBAUDWRPRY-WNBAZHKDSA-N
Smiles CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 4472.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.22 mL 1.12 mL 2.24 mL
5 mM 0.04 mL 0.22 mL 0.45 mL
10 mM 0.02 mL 0.11 mL 0.22 mL
50 mM 0 mL 0.02 mL 0.04 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Rivier et al (2007) Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668 PMID: 17335188

Rivier et al (2002) Receptor-selective corticotropin releasing factor analogs. Endocrin.Soc.Abstr. P2-50

Bruchas et al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528 PMID: 20052275


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Keywords: Stressin I, Stressin I supplier, CRF1, agonists, Corticotropin-Releasing, Factor1, Receptors, Factor, StressinI, cyclo(31-34)[D-Phe12,Nle21,38,Glu31,, Lys34]Ac-hCRF, (4-41), 1608, Tocris Bioscience

2 Citations for Stressin I

Citations are publications that use Tocris products. Selected citations for Stressin I include:

Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407 PMID: 18184783

Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology 70 316 PMID: 23470280


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Stressin 1 modulation of GABA transmission
By Anonymous on 05/10/2018
Assay Type: In Vitro
Species: Rat

Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.


Literature in this Area

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