STF 083010

Pricing Availability   Qty
Cat.No. 4509 - STF 083010 | C15H11NO3S2 | CAS No. 307543-71-1
Description: Inhibits IRE1α endonuclease activity
Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data

M. Wt 317.38
Formula C15H11NO3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 307543-71-1
PubChem ID 11487816
InChI Key RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 317.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713

Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465


If you know of a relevant reference for STF 083010, please let us know.

View Related Products by Target

View Related Products by Product Action

View all IRE1 Inhibitors

Keywords: STF 083010, STF 083010 supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, inhibits, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum, IRE1, 4509, Tocris Bioscience

3 Citations for STF 083010

Citations are publications that use Tocris products. Selected citations for STF 083010 include:

Ko et al (2017) Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep 7 14940 PMID: 29097726

Chen et al (2018) IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation 15 32 PMID: 29394934

Kim et al (2015) Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production. Cell Death Dis 194 4498 PMID: 25821218


Do you know of a great paper that uses STF 083010 from Tocris? Please let us know.

Reviews for STF 083010

There are currently no reviews for this product. Be the first to review STF 083010 and earn rewards!

Have you used STF 083010?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells