STF 083010

Pricing Availability Delivery Time Qty
Cat.No. 4509 - STF 083010 | C15H11NO3S2 | CAS No. 307543-71-1
Description: Inhibits IRE1α endonuclease activity
Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data

M. Wt 317.38
Formula C15H11NO3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 307543-71-1
PubChem ID 11487816
InChI Key RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 317.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713

Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465


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Keywords: STF083010 IRE1alpha IRE1a IRE1α inhibitors inhibits endonucleases RNases XBP mRNA splicing inositol requiring enzyme endoplasmic reticulum IRE1

1 Citation for STF 083010

Citations are publications that use Tocris products. Selected citations for STF 083010 include:

Kim et al (2015) Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production. Cell Death Dis 194 4498 PMID: 25821218


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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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