You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for STF 083010
STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.
Technical Data for STF 083010
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for STF 083010
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for STF 083010
The following data is based on the product molecular weight 317.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.15 mL||15.75 mL||31.51 mL|
|5 mM||0.63 mL||3.15 mL||6.3 mL|
|10 mM||0.32 mL||1.58 mL||3.15 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References for STF 083010
References are publications that support the biological activity of the product.
Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713
Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465
If you know of a relevant reference for STF 083010, please let us know.
View Related Products by Product Action
Keywords: STF 083010, STF 083010 supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, inhibits, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum, IRE1, 4509, Tocris Bioscience
4 Citations for STF 083010
Citations are publications that use Tocris products. Selected citations for STF 083010 include:
Ko et al (2017) Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep 7 14940 PMID: 29097726
Chen et al (2018) IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation 15 32 PMID: 29394934
Xu et al (2019) The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight 4 PMID: 30843874
Kim et al (2015) Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production. Cell Death Dis 194 4498 PMID: 25821218
Do you know of a great paper that uses STF 083010 from Tocris? Please let us know.
Reviews for STF 083010
There are currently no reviews for this product. Be the first to review STF 083010 and earn rewards!
Have you used STF 083010?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets