SR 2640 hydrochloride

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Cat.No. 1804 - SR 2640 hydrochloride | C23H18N2O3.HCl | CAS No. 146662-42-2
Description: Potent, selective LTD4 /LTE4 receptor antagonist
Chemical Name: 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.

Compound Libraries

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Technical Data

M. Wt 406.87
Formula C23H18N2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 146662-42-2
PubChem ID 45073453
InChI Key KDSYWFCTUKABKE-UHFFFAOYSA-N
Smiles Cl.OC(=O)C1=CC=CC=C1NC1=CC(OCC2=CC=C3C=CC=CC3=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.34 50

Preparing Stock Solutions

The following data is based on the product molecular weight 406.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.92 mL 24.58 mL 49.16 mL
2.5 mM 0.98 mL 4.92 mL 9.83 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ahnfelt-Ronne et al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117 PMID: 2854067

Bouchelouche et al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299 PMID: 2160189

Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291 PMID: 2546563


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Citations for SR 2640 hydrochloride

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