SR 2640 hydrochloride

Discontinued Product

SR 2640 hydrochloride (Cat. No. 1804) has been withdrawn from sale for commercial reasons.
Description: Potent, selective LTD4 /LTE4 receptor antagonist
Chemical Name: 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for SR 2640 hydrochloride

SR 2640 hydrochloride is a potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.

Technical Data for SR 2640 hydrochloride

M. Wt 406.87
Formula C23H18N2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 146662-42-2
PubChem ID 45073453
Smiles Cl.OC(=O)C1=CC=CC=C1NC1=CC(OCC2=CC=C3C=CC=CC3=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SR 2640 hydrochloride

Certificate of Analysis / Product Datasheet
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References for SR 2640 hydrochloride

References are publications that support the biological activity of the product.

Ahnfelt-Ronne et al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117 PMID: 2854067

Bouchelouche et al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299 PMID: 2160189

Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291 PMID: 2546563

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Keywords: SR 2640 hydrochloride, SR 2640 hydrochloride supplier, Potent, selective, LTD4, /LTE4, receptors, antagonists, leukotrienes, eicosanoids, SR2640, hydrochloride, Leukotriene, and, Related, Receptors, 1804, Tocris Bioscience

1 Citation for SR 2640 hydrochloride

Citations are publications that use Tocris products. Selected citations for SR 2640 hydrochloride include:

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414

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