You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
SR 2640 hydrochloride
Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 406.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.92 mL||24.58 mL||49.16 mL|
|2.5 mM||0.98 mL||4.92 mL||9.83 mL|
|5 mM||0.49 mL||2.46 mL||4.92 mL|
|25 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Ahnfelt-Ronne et al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117 PMID: 2854067
Bouchelouche et al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299 PMID: 2160189
Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291 PMID: 2546563
If you know of a relevant reference for SR 2640 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 2640 hydrochloride, SR 2640 hydrochloride supplier, Potent, selective, LTD4, /LTE4, receptors, antagonists, leukotrienes, eicosanoids, SR2640, hydrochloride, Leukotriene, and, Related, Receptors, 1804, Tocris Bioscience
Citations for SR 2640 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for SR 2640 hydrochloride. Do you know of a great paper that uses SR 2640 hydrochloride from Tocris? Please let us know.
Reviews for SR 2640 hydrochloride
There are currently no reviews for this product. Be the first to review SR 2640 hydrochloride and earn rewards!
Have you used SR 2640 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.