SR 13800

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Cat.No. 5431 - SR 13800 | C25H29N3O2S | CAS No. 227321-12-2
Description: Potent MCT1 inhibitor
Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
Purity: ≥98% (HPLC)

Biological Activity

Potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

Technical Data

M. Wt 435.58
Formula C25H29N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 227321-12-2
PubChem ID 5282542
Smiles O=C1N(C)N=C(CC(C)C)C2=CN(CC3=C(C=CC=C4)C4=CC=C3)C(SCCCO)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.56 100
ethanol 8.71 20

Preparing Stock Solutions

The following data is based on the product molecular weight 435.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371 PMID: 16370372

Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317 PMID: 25068893

If you know of a relevant reference for SR 13800, please let us know.

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Citations for SR 13800

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A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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