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Biological Activity for SR 13800
SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.
Technical Data for SR 13800
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 13800
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SR 13800
The following data is based on the product molecular weight 435.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.3 mL||11.48 mL||22.96 mL|
|5 mM||0.46 mL||2.3 mL||4.59 mL|
|10 mM||0.23 mL||1.15 mL||2.3 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for SR 13800
References are publications that support the biological activity of the product.
Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371 PMID: 16370372
Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317 PMID: 25068893
If you know of a relevant reference for SR 13800, please let us know.
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Keywords: SR 13800, SR 13800 supplier, SR13800, potent, MCT1, inhibitors, inhibits, lactate, uptake, anticancer, antitumour, antitumor, SLC16A1, monocarboxylate, transporters, Monocarboxylate, Transporters, 5431, Tocris Bioscience
2 Citations for SR 13800
Citations are publications that use Tocris products. Selected citations for SR 13800 include:
Maacha et al (2018) AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia 20 1008 PMID: 30189359
Liu et al (2017) The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab 26 719 PMID: 28965825
Do you know of a great paper that uses SR 13800 from Tocris? Please let us know.
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Literature in this Area
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