SR 13800

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Description: Potent MCT1 inhibitor
Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
Purity: ≥98% (HPLC)
Citations (4)
Literature (2)

Biological Activity for SR 13800

SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

Technical Data for SR 13800

M. Wt 435.58
Formula C25H29N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 227321-12-2
PubChem ID 5282542
Smiles O=C1N(C)N=C(CC(C)C)C2=CN(CC3=C(C=CC=C4)C4=CC=C3)C(SCCCO)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 13800

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.56 100
ethanol 8.71 20

Preparing Stock Solutions for SR 13800

The following data is based on the product molecular weight 435.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for SR 13800

References are publications that support the biological activity of the product.

Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371 PMID: 16370372

Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317 PMID: 25068893

If you know of a relevant reference for SR 13800, please let us know.

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Keywords: SR 13800, SR 13800 supplier, SR13800, potent, MCT1, inhibitors, inhibits, lactate, uptake, anticancer, antitumour, antitumor, SLC16A1, monocarboxylate, transporters, Monocarboxylate, Transporters, 5431, Tocris Bioscience

4 Citations for SR 13800

Citations are publications that use Tocris products. Selected citations for SR 13800 include:

Joselyn et al (2022) A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer. Cells 11 PMID: 35406740

Alejandra et al (2023) Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models. Int J Mol Sci 24 PMID: 37175628

Liu et al (2017) The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab 26 719 PMID: 28965825

Maacha et al (2018) AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia 20 1008 PMID: 30189359

Do you know of a great paper that uses SR 13800 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.