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SPT Imidazopyridine 1
Biological Activity for SPT Imidazopyridine 1
SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.
Technical Data for SPT Imidazopyridine 1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SPT Imidazopyridine 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SPT Imidazopyridine 1
The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.72 mL||27.44 mL|
|5 mM||0.55 mL||2.74 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
Product Datasheets for SPT Imidazopyridine 1
References for SPT Imidazopyridine 1
References are publications that support the biological activity of the product.
Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID: 27213958
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Keywords: SPT Imidazopyridine 1, SPT Imidazopyridine 1 supplier, serine, palmitoyl, transferase, SPT, inhibitors, inhibits, potent, ceramides, hypercholesterolemia, sphingolipids, palmitoyltransferase, Other, Transferases, 6055, Tocris Bioscience
Citations for SPT Imidazopyridine 1
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