SPT Imidazopyridine 1

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Cat.No. 6055 - SPT Imidazopyridine 1 | C22H24N2O3 | CAS No. 1933533-18-6
Description: Potent serine palmitoyl transferase inhibitor
Chemical Name: 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid
Purity: ≥98%
Datasheet
Citations
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Literature

Biological Activity

Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.

Technical Data

M. Wt 364.44
Formula C22H24N2O3
Storage Store at +4°C
Purity ≥98%
CAS Number 1933533-18-6
Smiles CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(C=C3)CC(O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References

References are publications that support the biological activity of the product.

Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID: 27213958


If you know of a relevant reference for SPT Imidazopyridine 1, please let us know.

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Keywords: SPT Imidazopyridine 1, SPT Imidazopyridine 1 supplier, serine, palmitoyl, transferase, SPT, inhibitors, inhibits, potent, ceramides, hypercholesterolemia, sphingolipids, Other, Transferases, 6055, Tocris Bioscience

Citations for SPT Imidazopyridine 1

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