Spermine tetrahydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0958 - Spermine tetrahydrochloride | C10H26N4.4HCl | CAS No. 306-67-2
Description: Modulator at polyamine site
Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data

M. Wt 348.19
Formula C10H26N4.4HCl
Storage Desiccate at +4°C
CAS Number 306-67-2
PubChem ID 9384
InChI Key XLDKUDAXZWHPFH-UHFFFAOYSA-N
Smiles NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 348.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.36 mL 28.72 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Benveniste and Mayer (1993) Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131 PMID: 8229795

Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557

Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22 PMID: 8789355

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608


If you know of a relevant reference for Spermine tetrahydrochloride, please let us know.

View Related Products by Target

Keywords: Spermine tetrahydrochloride, supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

7 Citations for Spermine tetrahydrochloride

Citations are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:

McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868

Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373 PMID: 26174503

Soto et al (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci 34 11673 PMID: 25164663

Zonouzi et al (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci 14 1430 PMID: 21983683

Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol 31 12650 PMID: 21880926

Soto et al (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci 12 277 PMID: 19234459

Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192 PMID: 19357347


Do you know of a great paper that uses Spermine tetrahydrochloride from Tocris? If so please let us know.

Reviews for Spermine tetrahydrochloride

There are currently no reviews for this product. Be the first to review Spermine tetrahydrochloride and earn rewards!

Have you used Spermine tetrahydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Huntington's Disease

Huntington's Disease Poster

Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.