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Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 348.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.36 mL||28.72 mL|
|5 mM||0.57 mL||2.87 mL||5.74 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the biological activity of the product.
Benveniste and Mayer (1993) Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131 PMID: 8229795
Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557
Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22 PMID: 8789355
Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608
If you know of a relevant reference for Spermine tetrahydrochloride, please let us know.
Keywords: Spermine tetrahydrochloride, Spermine tetrahydrochloride supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, 0958, Tocris Bioscience
8 Citations for Spermine tetrahydrochloride
Citations are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:
Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373 PMID: 26174503
Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron 95 1129 PMID: 28823727
Soto et al (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci 12 277 PMID: 19234459
Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192 PMID: 19357347
McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868
Soto et al (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci 34 11673 PMID: 25164663
Zonouzi et al (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci 14 1430 PMID: 21983683
Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol 31 12650 PMID: 21880926
Do you know of a great paper that uses Spermine tetrahydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.