Spermine tetrahydrochloride

Pricing Availability   Qty
Description: Modulator at polyamine site
Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Citations (8)
Literature (6)

Biological Activity for Spermine tetrahydrochloride

Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data for Spermine tetrahydrochloride

M. Wt 348.19
Formula C10H26N4.4HCl
Storage Desiccate at +4°C
CAS Number 306-67-2
PubChem ID 9384

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Spermine tetrahydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 34.82 100

Preparing Stock Solutions for Spermine tetrahydrochloride

The following data is based on the product molecular weight 348.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.36 mL 28.72 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets for Spermine tetrahydrochloride

Certificate of Analysis / Product Datasheet
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References for Spermine tetrahydrochloride

References are publications that support the biological activity of the product.

Benveniste and Mayer (1993) Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131 PMID: 8229795

Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557

Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22 PMID: 8789355

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608

If you know of a relevant reference for Spermine tetrahydrochloride, please let us know.

View Related Products by Target

Keywords: Spermine tetrahydrochloride, Spermine tetrahydrochloride supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, 0958, Tocris Bioscience

8 Citations for Spermine tetrahydrochloride

Citations are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:

Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192 PMID: 19357347

Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron 95 1129 PMID: 28823727

McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868

Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373 PMID: 26174503

Do you know of a great paper that uses Spermine tetrahydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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