SN 003

Discontinued Product

SN 003 (Cat. No. 3294) has been withdrawn from sale for commercial reasons.
Description: Potent and selective CRF1 antagonist
Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SN 003

Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.

Technical Data for SN 003

M. Wt 355.43
Formula C19H25N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 197801-88-0
PubChem ID 10291750
Smiles CCC(COC)N2C1=CC(C)=NC(NC3=CC=C(OC)C=C3C)=C1N=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SN 003

References are publications that support the biological activity of the product.

Kumar et al (2006) Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg.Med.Chem. 14 4029 PMID: 16529935

Sullivan et al (2007) PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density? Nucl.Med.Biol 34 353 PMID: 17499724

Zhang et al (2003) Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic J.Pharm.Exp.Ther. 305 57

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Keywords: SN 003, SN 003 supplier, reversible, corticotropin, releasing, factor, receptors, 1, CRF1, CRF, antagonists, SN003, Receptors, 3294, Tocris Bioscience

Citations for SN 003

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Currently there are no citations for SN 003.

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