SN 003

Pricing Availability   Qty
Cat.No. 3294 - SN 003 | C19H25N5O2 | CAS No. 197801-88-0
Description: Potent and selective CRF1 antagonist
Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.

Technical Data

M. Wt 355.43
Formula C19H25N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 197801-88-0
PubChem ID 10291750
InChI Key FZMBHAQCHCEGNN-UHFFFAOYSA-N
Smiles CCC(COC)N2C1=CC(C)=NC(NC3=CC=C(OC)C=C3C)=C1N=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 35.54 100
DMSO 35.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 355.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.13 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References

References are publications that support the biological activity of the product.

Kumar et al (2006) Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg.Med.Chem. 14 4029 PMID: 16529935

Sullivan et al (2007) PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density? Nucl.Med.Biol 34 353 PMID: 17499724

Zhang et al (2003) Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic J.Pharm.Exp.Ther. 305 57


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Keywords: SN 003, SN 003 supplier, reversible, corticotropin, releasing, factor, receptors, 1, CRF1, CRF, antagonists, SN003, Receptors, 3294, Tocris Bioscience

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