SJ 6986

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Description: Molecular glue; induces degradation of GSPT1/2
Chemical Name: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for SJ 6986

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 6986

M. Wt 497.4
Formula C20H14F3N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2765625-93-0
PubChem ID 155925914
Smiles O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C(C=C2)C3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJ 6986

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.74 100

Preparing Stock Solutions for SJ 6986

The following data is based on the product molecular weight 497.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.05 mL 20.1 mL
5 mM 0.4 mL 2.01 mL 4.02 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for SJ 6986

References are publications that support the biological activity of the product.

Nishiguchi et al (2021) Identification of potent, selective, and orally bioavailable small- molecule GSPT1/2 degraders from a focused library of cereblon modulators. J.Med.Chem. 64 7296 PMID: 34042448

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Keywords: SJ 6986, SJ 6986 supplier, SJ6986, GSPT1/2, molecular, glue, degraders, degrades, apoptosis, ubiquitination, orally, bioavailable, potent, selective, Molecular, Glues, 7720, Tocris Bioscience

Citations for SJ 6986

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

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