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Biological Activity for SHIN 1
SHIN 1 is a potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.
Sold under license from Princeton University.
Technical Data for SHIN 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SHIN 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SHIN 1
The following data is based on the product molecular weight 400.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.99 mL||24.97 mL||49.94 mL|
|2.5 mM||1 mL||4.99 mL||9.99 mL|
|5 mM||0.5 mL||2.5 mL||4.99 mL|
|25 mM||0.1 mL||0.5 mL||1 mL|
References for SHIN 1
References are publications that support the biological activity of the product.
Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064
If you know of a relevant reference for SHIN 1, please let us know.
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Keywords: SHIN 1, SHIN 1 supplier, SHIN1, SHMT1, SHMT2, serine, hydroxymethyl, transferase, inhibitors, inhibits, potent, THF, tetrahydrofolate, Other, Transferases, 6998, Tocris Bioscience
1 Citation for SHIN 1
Citations are publications that use Tocris products. Selected citations for SHIN 1 include:
Vamsi K et al (2021) SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication. Nat Commun 12 1676 PMID: 33723254
Do you know of a great paper that uses SHIN 1 from Tocris? Please let us know.
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