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SHIN 1 New
Potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.
Sold under license from Princeton University.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 400.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.99 mL||24.97 mL||49.94 mL|
|2.5 mM||1 mL||4.99 mL||9.99 mL|
|5 mM||0.5 mL||2.5 mL||4.99 mL|
|25 mM||0.1 mL||0.5 mL||1 mL|
References are publications that support the biological activity of the product.
Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064
If you know of a relevant reference for SHIN 1, please let us know.
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Keywords: SHIN 1, SHIN 1 supplier, SHIN1, SHMT1, SHMT2, serine, hydroxymethyl, transferase, inhibitors, inhibits, potent, THF, tetrahydrofolate, Other, Transferases, 6998, Tocris Bioscience
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