SHIN 1

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Cat.No. 6998 - SHIN 1 | C24H24N4O2 | CAS No. 2146095-85-2
Description: Potent SHMT inhibitor
Chemical Name: 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.

Licensing Information

Sold under license from Princeton University.

Technical Data

M. Wt 400.48
Formula C24H24N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2146095-85-2
PubChem ID 134335083
InChI Key VVVOFJZXKJKHTD-UHFFFAOYSA-N
Smiles CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 400.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.99 mL 24.97 mL 49.94 mL
2.5 mM 1 mL 4.99 mL 9.99 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
25 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064


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Citations for SHIN 1

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Literature in this Area

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