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Submit ReviewSGI 1027
Description: DNA methyltransferase inhibitor
Chemical Name: N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Purity: ≥99% (HPLC)
Biological Activity for SGI 1027
SGI 1027 is a DNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC50 values are 7.5, 8 and 12.5 μM with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.
Technical Data for SGI 1027
| M. Wt | 461.52 |
| Formula | C27H23N7O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1020149-73-8 |
| PubChem ID | 24858111 |
| InChI Key | QSYLKMKIVWJAAK-UHFFFAOYSA-N |
| Smiles | O=C(NC4=CC=C(NC5=NC(N)=NC(C)=C5)C=C4)C(C=C3)=CC=C3NC2=CC=NC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SGI 1027
References for SGI 1027
References are publications that support the biological activity of the product.
Datta et al (2009) A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 69 4277 PMID: 19417133
García-Domínguez et al (2013) Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line. Bioorg.Med.Chem.Lett. 23 1631 PMID: 23402879
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Keywords: SGI 1027, SGI 1027 supplier, SGI1027, DNA, methyltransferase, inhibitors, inhibits, DNMT, TSGs, tumour, suppressor, genes, CpG, island, hypermethylation, Methyltransferases, 5155, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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