SGC 707

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Cat.No. 5367 - SGC 707 | C16H18N4O2
Description: Potent and selective allosteric inhibitor of PRMT3
Chemical Name: 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.

Compound Libraries

SGC 707 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 298.34
Formula C16H18N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 90642938
InChI Key DMIDPTCQPIJYFE-UHFFFAOYSA-N
Smiles O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 29.83 100
DMSO 29.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 298.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kaniskan et al (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl 54 5166 PMID: 25728001


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View Related Products by Product Action

View all Protein Arginine Methyltransferase Inhibitors

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Citations for SGC 707

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Literature in this Area

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Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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Pathways for SGC 707

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