SGC 6870

Pricing Availability   Qty
Description: Potent and selective PRMT6 allosteric inhibitor
Chemical Name: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for SGC 6870

SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM)

Negative control SGC 6870N (Cat. No. 7184) also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 6870 probe summary on the SGC website.

Compound Libraries for SGC 6870

SGC 6870 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for SGC 6870

M. Wt 469.4
Formula C23H21BrN2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2561471-27-8
PubChem ID 146026048
Smiles CC1=CC=C2C([C@@H](C3=CC(C)=CC(C)=C3)N(C(C4=CC=C(Br)S4)=O)CC(N2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SGC 6870

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.94 100
ethanol 46.94 100

Preparing Stock Solutions for SGC 6870

The following data is based on the product molecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for SGC 6870

References are publications that support the biological activity of the product.

Shen et al (2021) A first-in-class, highly selective and cell-active allosteric inhibitor of protein arginine methyltransferase 6 (PRMT6) J.Med.Chem. 64 3697 PMID: 33591753

If you know of a relevant reference for SGC 6870, please let us know.

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Keywords: SGC 6870, SGC 6870 supplier, SGC6870, Potent, selective, PRMT6, inhibitors, inhibits, allosteric, Protein, Arginine, Methyltransferases, 7182, Tocris Bioscience

Citations for SGC 6870

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