SEN 177

Pricing Availability   Qty
Cat.No. 6979 - SEN 177 | C18H19FN6 | CAS No. 2117405-13-5
Description: Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47
Chemical Name: 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for SEN 177

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.

Technical Data for SEN 177

M. Wt 338.39
Formula C18H19FN6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2117405-13-5
PubChem ID 91618245
InChI Key AJIAMIPUWJQSPR-UHFFFAOYSA-N
Smiles FC=1N=CC(=CC1)C2=CC=CN=C2N3CCC(C4=NN=CN4C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SEN 177

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.77 20
ethanol 6.77 20

Preparing Stock Solutions for SEN 177

The following data is based on the product molecular weight 338.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.78 mL 73.88 mL 147.76 mL
1 mM 2.96 mL 14.78 mL 29.55 mL
2 mM 1.48 mL 7.39 mL 14.78 mL
10 mM 0.3 mL 1.48 mL 2.96 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SEN 177

References are publications that support the biological activity of the product.

Jimenez-Sanchez et al (2015) siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nat.Chem.Biol. 11 347 PMID: 25848931

Logtenberg et al (2019) Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat.Med. 25 612 PMID: 30833751


If you know of a relevant reference for SEN 177, please let us know.

View Related Products by Product Action

View all Other Transferase Inhibitors

Keywords: SEN 177, SEN 177 supplier, SEN177, QPCT, glutaminyl, cyclase, inhibitors, potent, huntingtin, mHTT, Huntingtons, aggregates, CD47, SIRPa, SIRPalpha, Other, Transferases, Immune, Checkpoints, 6979, Tocris Bioscience

Citations for SEN 177

Citations are publications that use Tocris products.

Currently there are no citations for SEN 177. Do you know of a great paper that uses SEN 177 from Tocris? Please let us know.

Reviews for SEN 177

There are currently no reviews for this product. Be the first to review SEN 177 and earn rewards!

Have you used SEN 177?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review