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Cat.No. 1836 - Seglitide | cyclo(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe) | CAS No. 81377-02-8
Description: sst2 and sst5 agonist
Alternative Names: MK 678

Biological Activity

Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).

Technical Data

M. Wt 808.98
Formula C44H56N8O7
Sequence AYWKVF

(Modifications: Ala-1 = N-methyl-Ala, Trp-3 = D-Trp, Cyclized)

Storage Desiccate at -20°C
CAS Number 81377-02-8
PubChem ID 5311430
Smiles CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CC2=CC=CC=C2)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 808.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.18 mL 12.36 mL
5 mM 0.25 mL 1.24 mL 2.47 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441 PMID: 7870182

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15 PMID:

If you know of a relevant reference for Seglitide, please let us know.

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Keywords: Seglitide, supplier, sst2, sst5, agonists, Receptors, Somatostatin, MK678, MK, 678, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience

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