Discontinued Product

Seglitide (Cat. No. 1836) has been withdrawn from sale for commercial reasons.
Description: sst2 and sst5 agonist
Alternative Names: MK 678

Biological Activity for Seglitide

Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).

Technical Data for Seglitide

M. Wt 808.98
Formula C44H56N8O7
Sequence AYWKVF

(Modifications: Ala-1 = N-methyl-Ala, Trp-3 = D-Trp, Cyclized)

Storage Desiccate at -20°C
CAS Number 81377-02-8
PubChem ID 5311430
Smiles CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CC2=CC=CC=C2)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Seglitide

Certificate of Analysis / Product Datasheet
Select another batch:

References for Seglitide

References are publications that support the biological activity of the product.

Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441 PMID: 7870182

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15

View Related Products by Product Action

View all Somatostatin (sst) Receptor Agonists

Keywords: Seglitide, Seglitide supplier, sst2, sst5, agonists, Receptors, Somatostatin, MK678, MK, 678, 1836, Tocris Bioscience

Citations for Seglitide

Citations are publications that use Tocris products.

Currently there are no citations for Seglitide.

Reviews for Seglitide

There are currently no reviews for this product. Be the first to review Seglitide and earn rewards!

Have you used Seglitide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review