SDZ 220-581

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Description: Competitive NMDA antagonist
Chemical Name: (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for SDZ 220-581

SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for SDZ 220-581

M. Wt 369.74
Formula C16H17ClNO5P
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 174575-17-8
PubChem ID 128019
InChI Key VBRJFXSFCYEZMQ-HNNXBMFYSA-N
Smiles OC([C@@H](N)CC1=CC(C2=CC=CC=C2Cl)=CC(CP(O)(O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SDZ 220-581

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.24 25 with gentle warming
1.1eq. NaOH 36.97 100

Preparing Stock Solutions for SDZ 220-581

The following data is based on the product molecular weight 369.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.52 mL 27.05 mL
5 mM 0.54 mL 2.7 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for SDZ 220-581

Certificate of Analysis / Product Datasheet
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References for SDZ 220-581

References are publications that support the biological activity of the product.

Bakshi et al (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-MthD.-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 288 643 PMID: 9918570

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643 PMID: 8887974

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655 PMID: 8887975


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Citations for SDZ 220-581

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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