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Submit ReviewSDZ 220-581
Description: Competitive NMDA antagonist
Chemical Name: (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid
Purity: ≥98% (HPLC)
Biological Activity for SDZ 220-581
SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).
Licensing Information
Sold with the permission of Novartis Pharma AG
Technical Data for SDZ 220-581
| M. Wt | 369.74 |
| Formula | C16H17ClNO5P |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 174575-17-8 |
| PubChem ID | 128019 |
| InChI Key | VBRJFXSFCYEZMQ-HNNXBMFYSA-N |
| Smiles | OC([C@@H](N)CC1=CC(C2=CC=CC=C2Cl)=CC(CP(O)(O)=O)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SDZ 220-581
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.24 | 25 with gentle warming | |
| 1.1eq. NaOH | 36.97 | 100 |
Preparing Stock Solutions for SDZ 220-581
The following data is based on the product molecular weight 369.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.52 mL | 27.05 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.41 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for SDZ 220-581
References for SDZ 220-581
References are publications that support the biological activity of the product.
Bakshi et al (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-MthD.-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 288 643 PMID: 9918570
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643 PMID: 8887974
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655 PMID: 8887975
If you know of a relevant reference for SDZ 220-581, please let us know.
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Keywords: SDZ 220-581, SDZ 220-581 supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZ220-581, 1250, Tocris Bioscience
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