SDZ 220-040

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Cat.No. 1251 - SDZ 220-040 | C16H16Cl2NO6P | CAS No. 174575-40-7
Description: Potent, competitive NMDA antagonist
Chemical Name: (S)-α-Amino-2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid
Datasheet
Citations
Literature

Biological Activity

Potent competitive antagonist at the NMDA receptor (pKi = 8.5). Selective over a range of other receptor sites.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt 420.19
Formula C16H16Cl2NO6P
Storage Store at RT
CAS Number 174575-40-7
PubChem ID 128019
InChI Key VBRJFXSFCYEZMQ-HNNXBMFYSA-N
Smiles OC([C@@H](N)CC1=CC(C2=CC=C(Cl)C=C2Cl)=CC(CP(O)(O)=O)=C1O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 420.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.9 mL 23.8 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643 PMID: 8887974

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655 PMID: 8887975


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Citations for SDZ 220-040

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