Scrambled 10Panx

Pricing Availability Delivery Time Qty
Cat.No. 3708 - Scrambled 10Panx | Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg | CAS No. 1315378-72-3
Description: Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide
Alternative Names: scPanx
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Scrambled version of 10Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. 10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M. Wt 1242.37
Formula C58H79N15O16
Sequence FSVYWAQADR
Storage Store at -20°C
CAS Number 1315378-72-3
PubChem ID 90488872
InChI Key VNQGVHMGXBRHRA-QZHJRRRASA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 0.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1242.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.8 mL 4.02 mL 8.05 mL
5 mM 0.16 mL 0.8 mL 1.61 mL
10 mM 0.08 mL 0.4 mL 0.8 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor. EMBO J. 25 5071 PMID: 17036048

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431

Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555 PMID: 19056988


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Keywords: Scrambled 10Panx, Scrambled 10Panx supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, scpanx, Gap, 3708, Tocris Bioscience

1 Citation for Scrambled 10Panx

Citations are publications that use Tocris products. Selected citations for Scrambled 10Panx include:

Albalawi et al (2017) The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci 11 227 PMID: 28848393


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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