Sarcosine

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Cat.No. 2975 - Sarcosine | C3H7NO2 | CAS No. 107-97-1
Description: GlyT1 inhibitor
Chemical Name: N-Methylglycine
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site.

Technical Data

M. Wt 89.09
Formula C3H7NO2
Storage Store at RT
CAS Number 107-97-1
PubChem ID 1088
InChI Key FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Smiles OC(CNC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 89.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 11.22 mL 56.12 mL 112.25 mL
5 mM 2.24 mL 11.22 mL 22.45 mL
10 mM 1.12 mL 5.61 mL 11.22 mL
50 mM 0.22 mL 1.12 mL 2.24 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tsai et al (2004) Glycine transporter I inhibitor, N-methylglycine (Sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol.Psychiatry 55 452 PMID: 15023571

Singh and Singh (2011) Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 25 859 PMID: 21936588


If you know of a relevant reference for Sarcosine, please let us know.

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Keywords: Sarcosine, supplier, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, Glycine, Transporters, Tocris Bioscience

1 Citation for Sarcosine

Citations are publications that use Tocris products. Selected citations for Sarcosine include:

Yoshikawa et al (2012) Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. Eur Urol 62 704 PMID: 22341128


Do you know of a great paper that uses Sarcosine from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for Sarcosine

Protocols

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