Sarafotoxin S6b

Pricing Availability Delivery Time Qty
Cat.No. 1174 - Sarafotoxin S6b | Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11) | CAS No. 116303-65-2
Description: Endothelin receptor agonist; non-selective
Datasheet
Citations

Biological Activity

Vasoconstrictor peptide; non-selective endothelin receptor agonist.

Technical Data

M. Wt 2564
Formula C110H159N27O34S5
Sequence CSCKDMTDKECLYFCHQDVIW

(Modifications: Disulfide bridge between: 1-15, 3-11)

Storage Desiccate at -20°C
CAS Number 116303-65-2
PubChem ID 71308726
InChI Key ZHRYDGYRZIWZPS-RAALVGGVSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile

Preparing Stock Solutions

The following data is based on the product molecular weight 2564. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.39 mL 1.95 mL 3.9 mL
5 mM 0.08 mL 0.39 mL 0.78 mL
10 mM 0.04 mL 0.2 mL 0.39 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Aimoto et al (1990) Studies on the disulfide bridges of sarafotoxins. Chemical synthesis of sarafotoxin S6B and its homologue with different disulfide bridges. Biochem.Int. 21 1051 PMID: 2080919

Bax et al (1994) Different endothelin receptors involved in endothelin-1- and sarafotoxin S6B-induced contractions of the human isolated coronary artery. Br.J.Pharmacol. 113 1471 PMID: 7889304

Devadason and Henry (1997) Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Br.J.Pharmacol. 121 253 PMID: 9154335


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Keywords: Endothelin receptor agonists non-selective Non-Selective ET Receptors ETA ETB SarafotoxinS6b Non-selective Endothelin Peptide

Citations for Sarafotoxin S6b

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