Sarafotoxin S6a

Pricing Availability Delivery Time Qty
Cat.No. 1899 - Sarafotoxin S6a | Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11) | CAS No. 126738-34-9
Description: Endothelin receptor agonist
Datasheet
Citations

Biological Activity

Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.

Technical Data

M. Wt 2514.85
Formula C105H156N28O34S5
Sequence CSCKDMTDKECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Storage Desiccate at -20°C
CAS Number 126738-34-9
PubChem ID 71308664
InChI Key BOQKWORWRAYXSI-SQCNKGOOSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2514.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.4 mL 1.99 mL 3.98 mL
5 mM 0.08 mL 0.4 mL 0.8 mL
10 mM 0.04 mL 0.2 mL 0.4 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Minkes et al (1992) Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds. Am.J.Physiol. 262 H852 PMID: 1348398

Raffa et al (1996) Endothelin-induced nociception in mice: mediation by ETA and ETB receptors. J.Pharmacol.Exp.Ther. 276 647 PMID: 8632332

Schoeffter and Randriantsoa (1993) Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur.J.Pharmacol. 249 199 PMID: 8287901


If you know of a relevant reference for Sarafotoxin S6a, please let us know.

View Related Products by Target

Keywords: Endothelin receptor agonists Non-Selective ET Receptors SarafotoxinS6a Non-selective Endothelin Peptide

Citations for Sarafotoxin S6a

Citations are publications that use Tocris products.

Currently there are no citations for Sarafotoxin S6a. Do you know of a great paper that uses Sarafotoxin S6a from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for Sarafotoxin S6a

Protocols

TODO: Add Protocols