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Salvinorin B

Cat. No. 5611 Submit a Review Datasheet / COA / SDS
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Cat.No. 5611 - Salvinorin B | C21H26O7 | CAS No. 92545-30-7
Description: Activates the κ-opioid DREADD (KORD)
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A (Cat. No. 2134).

Technical Data

M. Wt 390.43
Formula C21H26O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 92545-30-7
PubChem ID 11440685
InChI Key BLTMVAIOAAGYAR-CEFSSPBYSA-N
Smiles O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.81 20

Preparing Stock Solutions

The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.81 mL 64.03 mL 128.06 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
2 mM 1.28 mL 6.4 mL 12.81 mL
10 mM 0.26 mL 1.28 mL 2.56 mL

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Product Datasheets

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References

References are publications that support the biological activity of the product.

Vardy et al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936 PMID: 25937170

Ansonoff et al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641 PMID: 16672569

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Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.

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