Salvinorin B

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Cat.No. 5611 - Salvinorin B | C21H26O7 | CAS No. 92545-30-7
Description: Activates the κ-opioid DREADD (KORD)
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A (Cat. No. 2134).

Technical Data

M. Wt 390.43
Formula C21H26O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 92545-30-7
PubChem ID 11440685
InChI Key BLTMVAIOAAGYAR-CEFSSPBYSA-N
Smiles O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.81 20

Preparing Stock Solutions

The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Vardy et al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936 PMID: 25937170

Ansonoff et al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641 PMID: 16672569


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Keywords: Activates κ-opioid designer receptors drugs KORD DREADDs salvinorin A agonists agonism DREADDs

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GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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Pathways for Salvinorin B

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