Salvinorin B
Biological Activity
Potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A (Cat. No. 2134).
Technical Data
| M. Wt | 390.43 |
| Formula | C21H26O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 92545-30-7 |
| PubChem ID | 11440685 |
| InChI Key | BLTMVAIOAAGYAR-CEFSSPBYSA-N |
| Smiles | O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.81 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Vardy et al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936 PMID: 25937170
Ansonoff et al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641 PMID: 16672569
If you know of a relevant reference for Salvinorin B, please let us know.
View Related Products by Target
Keywords: Activates κ-opioid designer receptors drugs KORD DREADDs salvinorin A agonists agonism DREADDs
Citations for Salvinorin B
Citations are publications that use Tocris products.
Currently there are no citations for Salvinorin B. Do you know of a great paper that uses Salvinorin B from Tocris? If so please let us know.
