Home / Product Type / Chemogenetics / DREADD Ligands / Salvinorin B

Salvinorin B

Cat. No. 5611 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 5611 - Salvinorin B | C21H26O7 | CAS No. 92545-30-7
Description: Activates the κ-opioid DREADD (KORD)
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A (Cat. No. 2134).

Technical Data

M. Wt 390.43
Formula C21H26O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 92545-30-7
PubChem ID 11440685
InChI Key BLTMVAIOAAGYAR-CEFSSPBYSA-N
Smiles O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.81 20

Preparing Stock Solutions

The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.81 mL 64.03 mL 128.06 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
2 mM 1.28 mL 6.4 mL 12.81 mL
10 mM 0.26 mL 1.28 mL 2.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the biological activity of the product.

Vardy et al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936 PMID: 25937170

Ansonoff et al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641 PMID: 16672569

If you know of a relevant reference for Salvinorin B, please let us know.

View Related Products by Target

Keywords: Salvinorin B, Salvinorin B supplier, Activates, κ-opioid, designer, receptors, drugs, KORD, DREADDs, salvinorin, A, agonists, agonism, Kappa, Opioid, Receptors, 5611, Tocris Bioscience

1 Citation for Salvinorin B

Citations are publications that use Tocris products. Selected citations for Salvinorin B include:

Smith et al (2016) DREADDS: Use and application in behavioral neuroscience. Behav Neurosci 130 137 PMID: 26913540

Do you know of a great paper that uses Salvinorin B from Tocris? Please let us know.

Reviews for Salvinorin B

There are currently no reviews for this product. Be the first to review Salvinorin B and earn rewards!

Have you used Salvinorin B?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Chemogenetics

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.

Allosteric GPCR Pharmacology

Allosteric GPCR Pharmacology Poster

G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster highlights some of the key insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.

GPCR Efficacy and Biased Agonism

GPCR Efficacy and Biased Agonism Poster

GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.