S 32826

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Cat.No. 3404 - S 32826 | C21H34NO4PNa2 | CAS No. 1103672-43-0
Description: Potent autotaxin inhibitor
Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).

Technical Data

M. Wt 441.45
Formula C21H34NO4PNa2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1103672-43-0
PubChem ID 71311878
Smiles [Na+].[Na+].CCCCCCCCCCCCCC(=O)NC1=CC=C(CP([O-])([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 44.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 441.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References are publications that support the biological activity of the product.

Ferry et al (2008) S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J.Pharmacol.Exp.Ther. 327 809 PMID: 18755937

Li et al (2011) Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Mol.Cancer 10 18 PMID: 21314984

Gaetano et al (2009) Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells. Mol.Carcinogenesis 48 801

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Citations for S 32826

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