S 32826
Biological Activity
Inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).
Technical Data
| M. Wt | 441.45 |
| Formula | C21H34NO4PNa2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1103672-43-0 |
| PubChem ID | 71311878 |
| InChI Key | DGRFALMFDGBLCP-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].CCCCCCCCCCCCCC(=O)NC1=CC=C(CP([O-])([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 44.15 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 441.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.33 mL | 22.65 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.53 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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References
References are publications that support the products' biological activity.
Ferry et al (2008) S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J.Pharmacol.Exp.Ther. 327 809 PMID: 18755937
Li et al (2011) Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Mol.Cancer 10 18 PMID: 21314984
Gaetano et al (2009) Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells. Mol.Carcinogenesis 48 801 PMID:
If you know of a relevant reference for S 32826, please let us know.
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Keywords: S 32826, supplier, S32826, autotaxin, atx, inhibits, inhibitors, LPA, lysophosphatidic, acid, lipids, enpp2, lysophospholipases, phospholipases, Autotaxin, Tocris Bioscience
Citations for S 32826
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