S 107 hydrochloride

Discontinued Product

S 107 hydrochloride (Cat. No. 3893) has been withdrawn from sale for commercial reasons.
Cat.No. 3893 - S 107 hydrochloride | C11H15NOS.HCl | CAS No. 927871-76-9
Description: RyR1 stabilizer; inhibits Ca2+ leak from the SR
Chemical Name: 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity

Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca2+ leak from the sarcoplasmic reticulum (SR). Activity results in improved muscle function and increased exercise performance in a Duchenne muscular dystrophy (DMD) mouse model (mdx). Also reduces exercise-induced muscle damage by lowering calpain activation and plasma creatine kinase levels.

Technical Data

M. Wt 245.77
Formula C11H15NOS.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 927871-76-9
Smiles CN2CCSC1=CC=C(OC)C=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Bellinger et al (2008) Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc.Natl.Acad.Sci. 105 2198

Bellinger et al (2009) Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle. Nature Med. 15 325

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