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S 107 hydrochloride
Discontinued ProductS 107 hydrochloride (Cat. No. 3893) has been withdrawn from sale for commercial reasons.
Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca2+ leak from the sarcoplasmic reticulum (SR). Activity results in improved muscle function and increased exercise performance in a Duchenne muscular dystrophy (DMD) mouse model (mdx). Also reduces exercise-induced muscle damage by lowering calpain activation and plasma creatine kinase levels.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bellinger et al (2008) Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc.Natl.Acad.Sci. 105 2198
Bellinger et al (2009) Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle. Nature Med. 15 325
Keywords: S 107 hydrochloride, S 107 hydrochloride supplier, ryanodine, receptors, RyR1inhibits, inhibitors, calcium, Ca2+, leak, sarcoplasmic, reticulum, muscle, function, damage, S107, General, Calcium, Signaling, Agents, 3893, Tocris Bioscience
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