S 107 hydrochloride
Discontinued ProductUnfortunately S 107 hydrochloride (Cat. No. 3893) has been withdrawn from sale for commercial reasons.
Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca2+ leak from the sarcoplasmic reticulum (SR). Activity results in improved muscle function and increased exercise performance in a Duchenne muscular dystrophy (DMD) mouse model (mdx). Also reduces exercise-induced muscle damage by lowering calpain activation and plasma creatine kinase levels.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 245.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.07 mL||20.34 mL||40.69 mL|
|5 mM||0.81 mL||4.07 mL||8.14 mL|
|10 mM||0.41 mL||2.03 mL||4.07 mL|
|50 mM||0.08 mL||0.41 mL||0.81 mL|
References are publications that support the products' biological activity.
Keywords: S 107 hydrochloride, supplier, ryanodine, receptors, RyR1inhibits, inhibitors, calcium, Ca2+, leak, sarcoplasmic, reticulum, muscle, function, damage, S107, General, Calcium, Signaling, Agents, General, Calcium, Signaling, Agents, Tocris Bioscience
Citations for S 107 hydrochloride
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Currently there are no citations for S 107 hydrochloride.
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