(RS)-(Tetrazol-5-yl)glycine

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Cat.No. 0312 - (RS)-(Tetrazol-5-yl)glycine | C3H5N5O2 | CAS No. 138199-51-6
Description: Highly potent NMDA receptor agonist
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent NMDA receptor agonist, approximately 20 times more active than NMDA. Also available as part of the Mixed NMDA Receptor Tocriset™.

Technical Data

M. Wt 143.1
Formula C3H5N5O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 138199-51-6
PubChem ID 126383
InChI Key UKBRUIZWQZHXFL-UHFFFAOYSA-N
Smiles NC(C(O)=O)C1=NN=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 143.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.99 mL 34.94 mL 69.88 mL
5 mM 1.4 mL 6.99 mL 13.98 mL
10 mM 0.7 mL 3.49 mL 6.99 mL
50 mM 0.14 mL 0.7 mL 1.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Arnt et al (1995) Diffentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity. Eur.J.Pharmacol. 285 289 PMID: 8575516

Moroni et al (1995) NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S)cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid. Naunyn Schmiedebergs Arch.Pharmacol. 351 371 PMID: 7543185

Schoepp et al (1991) D,L-(Tetrazol-5-yl)glycine a novel and highly potent NMDA receptor agonist. Eur.J.Pharmacol. 203 237 PMID: 1686860


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Keywords: (RS)-(Tetrazol-5-yl)glycine, supplier, potent, NMDA, receptor, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

Citations for (RS)-(Tetrazol-5-yl)glycine

Citations are publications that use Tocris products.

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