(RS)-CPP

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Cat.No. 0173 - (RS)-CPP | C8H17N2O5P | CAS No. 100828-16-8
Description: Potent NMDA antagonist
Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Datasheet
Citations (20)
Reviews
Literature

Biological Activity

Potent NMDA antagonist.

R-enantiomer also available.

Technical Data

M. Wt 252.21
Formula C8H17N2O5P
Storage Desiccate at RT
CAS Number 100828-16-8
PubChem ID 1228
InChI Key CUVGUPIVTLGRGI-UHFFFAOYSA-N
Smiles O=C(C1NCCN(CCCP(O)(O)=O)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.65 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Davies et al (1986) CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity. Brain Res. 382 169 PMID: 2876749


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Keywords: (RS)-CPP, supplier, Potent, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

20 Citations for (RS)-CPP

Citations are publications that use Tocris products. Selected citations for (RS)-CPP include:

Voyer (2017) Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors Neuropharmacology 112 150 PMID: 27267684

Maag et al (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Front Neurosci 9 351 PMID: 26483626

Neuner et al (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281 69 PMID: 25513972

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Elife 4 PMID: 25723967

Zhao et al (2015) Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. J Neurosci 35 308 PMID: 25568123

Ferreira et al (2015) Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. Front Cell Neurosci 9 161 PMID: 25972785

Hooks et al (2015) Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci 35 4418 PMID: 25762684

Toyoizumi et al (2014) Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron 84 497 PMID: 25374364

Vaghi et al (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb Cortex 24 1247 PMID: 23258346

Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148 PMID: 25165854

Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits 7 179 PMID: 24273495

Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636 PMID: 20384810

Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci 31 1219 PMID: 20345918

Ziskin et al (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 10 321 PMID: 17293857

Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901 PMID: 16199519

Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci 25 5502 PMID: 15944378

Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551 PMID: 15140926

Abraham et al (2001) Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP. Proc Natl Acad Sci U S A 98 10924 PMID: 11517323

Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577 PMID: 8096780

Sacktor et al (1993) Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation. Proc Natl Acad Sci U S A 90 8342 PMID: 8378304


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