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RP 6306 New
Biological Activity for RP 6306
RP 6306 is a potent and selective PKMYT1 inhibitor (IC50 = 3.1 nM). In vivo, it inhibits CCNE1-amplified tumor cell growth in mouse xenograft models. RP 6306 is orally bioavailable.
Technical Data for RP 6306
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RP 6306
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RP 6306
The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for RP 6306
References are publications that support the biological activity of the product.
Gallo et al (2022) CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Nature 604 749 PMID: 35444283
Szychowski et al (2022) Discovery of an orally bioavailable and selective PKMYT1 inhibitor, RP-6306. J.Med.Chem. 65 10251 PMID: 35880755
If you know of a relevant reference for RP 6306, please let us know.
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Citations for RP 6306
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