RP 6306

Pricing Availability   Qty
Description: Potent and selective PKMYT1 inhibitor
Chemical Name: (S)-2-Amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for RP 6306

RP 6306 is a potent and selective PKMYT1 inhibitor (IC50 = 3.1 nM). In vivo, it inhibits CCNE1-amplified tumor cell growth in mouse xenograft models. RP 6306 is orally bioavailable.

Technical Data for RP 6306

M. Wt 324.38
Formula C18H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2719793-90-3
PubChem ID 156869388
Smiles O=C(C1=C(N)N(C2=C(C)C(O)=CC=C2C)C3=C1C=C(C)C(C)=N3)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RP 6306

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.44 100

Preparing Stock Solutions for RP 6306

The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for RP 6306

References are publications that support the biological activity of the product.

Gallo et al (2022) CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Nature 604 749 PMID: 35444283

Szychowski et al (2022) Discovery of an orally bioavailable and selective PKMYT1 inhibitor, RP-6306. J.Med.Chem. 65 10251 PMID: 35880755

If you know of a relevant reference for RP 6306, please let us know.

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Citations for RP 6306

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