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Cat.No. 3504 - Risedronate | C7H10NNaO7P2 | CAS No. 115436-72-1
Description: Farnesyl diphosphate (FPP) synthase inhibitor
Chemical Name: P,P'-[1-Hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic acid sodium salt
Purity: ≥99% (HPLC)

Biological Activity

Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 100 nM). Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone resorption in vivo.

Technical Data

M. Wt 305.09
Formula C7H10NNaO7P2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 115436-72-1
PubChem ID 68739
Smiles OC(P(O)(O)=O)(P([O-])(O)=O)CC1=CC=CN=C1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 3.05 10

Preparing Stock Solutions

The following data is based on the product molecular weight 305.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.39 mL 32.78 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Coxon et al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307 PMID: 16650801

Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945 PMID: 18974139

Stresing et al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16 PMID: 17697748

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603

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Keywords: Farnesyl diphosphate FPP inhibitors inhibits Synthases Synthetases Other Synthases/Synthetases

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Risedronate


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