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Risedronate is an orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 100 nM). Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone resorption in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 305.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||32.78 mL||163.89 mL||327.77 mL|
|0.5 mM||6.56 mL||32.78 mL||65.55 mL|
|1 mM||3.28 mL||16.39 mL||32.78 mL|
|5 mM||0.66 mL||3.28 mL||6.56 mL|
References are publications that support the biological activity of the product.
Coxon et al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307 PMID: 16650801
Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945 PMID: 18974139
Stresing et al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16 PMID: 17697748
Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603
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Keywords: Risedronate, Risedronate supplier, Farnesyl, diphosphate, FPP, inhibitors, inhibits, Synthases, Synthetases, Other, Synthases/Synthetases, 3504, Tocris Bioscience
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