Ribociclib

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Cat.No. 7050 - Ribociclib | C23H30N8O | CAS No. 1211441-98-3
Description: Dual cdk4/cdk6 inhibitor; orally bioavailable
Alternative Names: LEE-011
Chemical Name: 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.

Technical Data

M. Wt 434.54
Formula C23H30N8O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1211441-98-3
PubChem ID 44631912
InChI Key RHXHGRAEPCAFML-UHFFFAOYSA-N
Smiles CN(C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.35 10

Preparing Stock Solutions

The following data is based on the product molecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.06 mL 230.13 mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

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References

References are publications that support the biological activity of the product.

Rader et al (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 19 6173 PMID: 24045179


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Keywords: Ribociclib, Ribociclib supplier, Dual, cdk4, cdk6, inhibitors, inhibits, orally, bioavailable, LEE-011, Cyclin-dependent, Kinase, 7050, Tocris Bioscience

Citations for Ribociclib

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Literature in this Area

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