You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.01 mL||115.06 mL||230.13 mL|
|0.5 mM||4.6 mL||23.01 mL||46.03 mL|
|1 mM||2.3 mL||11.51 mL||23.01 mL|
|5 mM||0.46 mL||2.3 mL||4.6 mL|
References are publications that support the biological activity of the product.
Rader et al (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 19 6173 PMID: 24045179
If you know of a relevant reference for Ribociclib, please let us know.
View Related Products by Product Action
Keywords: Ribociclib, Ribociclib supplier, Dual, cdk4, cdk6, inhibitors, inhibits, orally, bioavailable, LEE-011, Cyclin-dependent, Kinase, 7050, Tocris Bioscience
Citations for Ribociclib
Citations are publications that use Tocris products.
Currently there are no citations for Ribociclib. Do you know of a great paper that uses Ribociclib from Tocris? Please let us know.
Reviews for Ribociclib
There are currently no reviews for this product. Be the first to review Ribociclib and earn rewards!
Have you used Ribociclib?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.