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Biological Activity for Ribociclib
Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.
Technical Data for Ribociclib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ribociclib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ribociclib
The following data is based on the product molecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.01 mL||115.06 mL||230.13 mL|
|0.5 mM||4.6 mL||23.01 mL||46.03 mL|
|1 mM||2.3 mL||11.51 mL||23.01 mL|
|5 mM||0.46 mL||2.3 mL||4.6 mL|
References for Ribociclib
References are publications that support the biological activity of the product.
Rader et al (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 19 6173 PMID: 24045179
If you know of a relevant reference for Ribociclib, please let us know.
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Keywords: Ribociclib, Ribociclib supplier, Dual, cdk4, cdk6, inhibitors, inhibits, orally, bioavailable, LEE-011, Cyclin-dependent, Kinase, CDK4, Subfamily, 7050, Tocris Bioscience
Citations for Ribociclib
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