Discontinued Product

RI-STAD 2 (Cat. No. 6567) has been withdrawn from sale for commercial reasons.
Description: AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
Literature (1)

Biological Activity for RI-STAD 2

RI-STAD 2 is an AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

Technical Data for RI-STAD 2

M. Wt 2401.75
Formula C109H181N25O35

(Modifications: Leu-1 = NH2-PEG3-CH2-CO-Leu, X = (S)-2-(4-pentenyl)alanine, X-2 and X-6 stapled together with a double bond)

Storage Store at -20°C
Smiles O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@](CCC/C=C/CCC[C@](NC([C@H](CC(C)C)NC(COCCOCCOCCN)=O)=O)(C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2C)=O)=O)=O)C)(NC2=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RI-STAD 2

References are publications that support the biological activity of the product.

Wang et al (2015) PKA-type I selective constrained peptide disruptors of AKAP complexes. ACS Chem.Biol. 10 1502 PMID: 25765284

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Keywords: RI-STAD 2, RI-STAD 2 supplier, RI-STAD2, stapled, peptide, selective, AKAP, disruptors, disrupts, a-kinase, anchoring, proteins, RI, PKA, protein, kinase, A, A-kinase-anchoring, protiens, Stapled, Peptides, 6567, Tocris Bioscience

Citations for RI-STAD 2

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Currently there are no citations for RI-STAD 2.

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Literature in this Area

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