Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
(Phe-8 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in 20% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 969.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.03 mL||5.16 mL||10.32 mL|
|5 mM||0.21 mL||1.03 mL||2.06 mL|
|10 mM||0.1 mL||0.52 mL||1.03 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the biological activity of the product.
Rizwan et al (2012) RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153 3770 PMID: 22691552
Ubuka et al (2009) Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4 e8400 PMID: 20027225
Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2 703 PMID: 11025660
If you know of a relevant reference for RFRP 3 (human), please let us know.
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Keywords: RFRP 3 (human), RFRP 3 (human) supplier, RFamide-related, peptide, RFRP3, neuropeptide, FF/AF, agonists, gonadotropin-inhibitory, gonadotrophin-inhibitory, hormone, homologs, orthologs, GnIH, Neuropeptide, NPVF, Receptors, 4683, Tocris Bioscience
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