RFRP 3 (human)

Pricing Availability Delivery Time Qty
Cat.No. 4683 - RFRP 3 (human) | Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2 | CAS No. 311309-27-0
Description: NPFF1 agonist; GnIH homolog
Alternative Names: Neuropeptide NPVF
Datasheet
Citations
Literature

Biological Activity

Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

Technical Data

M. Wt 969.15
Formula C45H72N14O10
Sequence VPNLPQRF

(Phe-8 = C-terminal amide)

Storage Store at -20°C
CAS Number 311309-27-0
PubChem ID 71451611
InChI Key JFZCLMZUABKABL-GVCDGELBSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 969.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.16 mL 10.32 mL
5 mM 0.21 mL 1.03 mL 2.06 mL
10 mM 0.1 mL 0.52 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rizwan et al (2012) RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153 3770 PMID: 22691552

Ubuka et al (2009) Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4 e8400 PMID: 20027225

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2 703 PMID: 11025660


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