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Submit ReviewRFRP 3 (human)
Description: NPFF1 agonist; GnIH homolog
Alternative Names: Neuropeptide NPVF
Purity: ≥95% (HPLC)
Biological Activity for RFRP 3 (human)
RFRP 3 (human) is an agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
Technical Data for RFRP 3 (human)
| M. Wt | 969.15 |
| Formula | C45H72N14O10 |
| Sequence |
VPNLPQRF (Phe-8 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 311309-27-0 |
| PubChem ID | 71451611 |
| InChI Key | JFZCLMZUABKABL-GVCDGELBSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RFRP 3 (human)
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for RFRP 3 (human)
References for RFRP 3 (human)
References are publications that support the biological activity of the product.
Rizwan et al (2012) RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153 3770 PMID: 22691552
Ubuka et al (2009) Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4 e8400 PMID: 20027225
Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2 703 PMID: 11025660
If you know of a relevant reference for RFRP 3 (human), please let us know.
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Keywords: RFRP 3 (human), RFRP 3 (human) supplier, RFamide-related, peptide, RFRP3, neuropeptide, FF/AF, agonists, gonadotropin-inhibitory, gonadotrophin-inhibitory, hormone, homologs, orthologs, GnIH, Neuropeptide, NPVF, Receptors, 4683, Tocris Bioscience
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