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RFRP-1 (human) is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
(Phe-12 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599
Nichols et al (2010) Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 31 2067 PMID: 20797420
Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2 703 PMID: 11025660
Keywords: RFRP-1 (human), RFRP-1 (human) supplier, neuropeptide, FF, receptors, NPFF1, NPFF2, GPR147, prolactin, RFamide-related, peptides, cardiac, myocytes, agonists, agonism, endogenous, Neuropeptide, FF/AF, Receptors, 5677, Tocris Bioscience
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