RFRP-1 (human)

Discontinued Product

RFRP-1 (human) (Cat. No. 5677) has been withdrawn from sale for commercial reasons.
Description: Potent NPFF receptor agonist

Biological Activity for RFRP-1 (human)

RFRP-1 (human) is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.

Technical Data for RFRP-1 (human)

M. Wt 1428.72
Formula C67H101N19O14S

(Phe-12 = C-terminal amide)

Storage Store at -20°C
CAS Number 311309-25-8
PubChem ID 71462794
Smiles [H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RFRP-1 (human)

References for RFRP-1 (human)

References are publications that support the biological activity of the product.

Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599

Nichols et al (2010) Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 31 2067 PMID: 20797420

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2 703 PMID: 11025660

View Related Products by Product Action

View all Neuropeptide FF/AF Receptor Agonists

Keywords: RFRP-1 (human), RFRP-1 (human) supplier, neuropeptide, FF, receptors, NPFF1, NPFF2, GPR147, prolactin, RFamide-related, peptides, cardiac, myocytes, agonists, agonism, endogenous, Neuropeptide, FF/AF, Receptors, 5677, Tocris Bioscience

Citations for RFRP-1 (human)

Citations are publications that use Tocris products.

Currently there are no citations for RFRP-1 (human).

Reviews for RFRP-1 (human)

There are currently no reviews for this product. Be the first to review RFRP-1 (human) and earn rewards!

Have you used RFRP-1 (human)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review