RFRP-1 (human)

Pricing Availability Delivery Time Qty
Cat.No. 5677 - RFRP-1 (human) | Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 | CAS No. 311309-25-8
Description: Potent NPFF receptor agonist

Biological Activity

Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.

Technical Data

M. Wt 1428.72
Formula C67H101N19O14S

(Phe-12 = C-terminal amide)

Storage Store at -20°C
CAS Number 311309-25-8
PubChem ID 71462794
Smiles [H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1428.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.7 mL 3.5 mL 7 mL
5 mM 0.14 mL 0.7 mL 1.4 mL
10 mM 0.07 mL 0.35 mL 0.7 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599

Nichols et al (2010) Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 31 2067 PMID: 20797420

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2 703 PMID: 11025660

If you know of a relevant reference for RFRP-1 (human), please let us know.

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Keywords: RFRP-1 (human), supplier, neuropeptide, FF, receptors, NPFF1, NPFF2, GPR147, prolactin, RFamide-related, peptides, cardiac, myocytes, agonists, agonism, endogenous, Neuropeptide, FF/AF, Receptors, Neuropeptide, FF/AF, Receptors, Tocris Bioscience

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