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Biological Activity for RF 9
RF 9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.
Technical Data for RF 9
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RF 9
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RF 9
The following data is based on the product molecular weight 482.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.72 mL||103.6 mL||207.2 mL|
|0.5 mM||4.14 mL||20.72 mL||41.44 mL|
|1 mM||2.07 mL||10.36 mL||20.72 mL|
|5 mM||0.41 mL||2.07 mL||4.14 mL|
References for RF 9
References are publications that support the biological activity of the product.
Wang et al (2008) Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 29 1183 PMID: 18406009
Simonin et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc.Natl.Acad.Sci.USA 103 466
Fang et al (2008) Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regul.Peptides 147 45
If you know of a relevant reference for RF 9, please let us know.
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Keywords: RF 9, RF 9 supplier, Selective, NPFF1, NPFF2, antagonists, npffr1, npffr2, Neuropeptide, FF, AF, Receptors, FF/AF, RF9, neuropeptides, 3672, Tocris Bioscience
2 Citations for RF 9
Citations are publications that use Tocris products. Selected citations for RF 9 include:
Lee et al (2017) Genetic and neuronal regulation of sleep by neuropeptide VF. Elife 6 PMID: 29106375
Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br J Pharmacol 171 701 PMID: 24138077
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Literature in this Area
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