Remodelin

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Cat.No. 5193 - Remodelin | C15H14N4S | CAS No. 949912-58-7
Description: N-acetyltransferase 10 (NAT10) inhibitor
Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

Compound Libraries

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Technical Data

M. Wt 282.36
Formula C15H14N4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 949912-58-7
PubChem ID 44442376
InChI Key XAEJIFARBQJLML-UHFFFAOYSA-N
Smiles N#CC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC/3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.24 100
ethanol 5.65 20

Preparing Stock Solutions

The following data is based on the product molecular weight 282.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Larrieu et al (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344 527 PMID: 24786082


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Keywords: Remodelin, supplier, NAT10, N-acetyltransferase, 10, aging, inhibitors, HGPS, Hutchinson-Gilford, progeria, syndrome, laminopathies, laminopathy, inhibits, Other, Transferases, Other, Transferases, Tocris Bioscience

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