Pricing Availability   Qty
Description: N-acetyltransferase 10 (NAT10) inhibitor
Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
Purity: ≥99% (HPLC)

Biological Activity for Remodelin

Remodelin is a N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

Technical Data for Remodelin

M. Wt 282.36
Formula C15H14N4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 949912-58-7
PubChem ID 44442376
Smiles N#CC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC/3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Remodelin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.24 100

Preparing Stock Solutions for Remodelin

The following data is based on the product molecular weight 282.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Remodelin

References are publications that support the biological activity of the product.

Larrieu et al (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344 527 PMID: 24786082

If you know of a relevant reference for Remodelin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Transferase Inhibitors

Keywords: Remodelin, Remodelin supplier, NAT10, N-acetyltransferase, 10, aging, inhibitors, HGPS, Hutchinson-Gilford, progeria, syndrome, laminopathies, laminopathy, inhibits, Other, Transferases, 5193, Tocris Bioscience

Citations for Remodelin

Citations are publications that use Tocris products.

Currently there are no citations for Remodelin. Do you know of a great paper that uses Remodelin from Tocris? Please let us know.

Reviews for Remodelin

There are currently no reviews for this product. Be the first to review Remodelin and earn rewards!

Have you used Remodelin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review