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Forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 424.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.78 mL||58.88 mL||117.76 mL|
|1 mM||2.36 mL||11.78 mL||23.55 mL|
|2 mM||1.18 mL||5.89 mL||11.78 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
References are publications that support the biological activity of the product.
Sun et al (2017) The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 10 eaai8583 PMID: 28420758
If you know of a relevant reference for RCM 1, please let us know.
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