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Cat.No. 6845 - RCM 1 | C20H12N2OS4 | CAS No. 339163-65-4
Description: FOXM1 inhibitor
Chemical Name: 2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.

Technical Data

M. Wt 424.58
Formula C20H12N2OS4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 339163-65-4
PubChem ID 4273985
Smiles O=C(C1=CC=CS1)CSC2=C(C(C3=CC=CS3)=CC(C4=CC=CS4)=N2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.49 20

Preparing Stock Solutions

The following data is based on the product molecular weight 424.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.78 mL 58.88 mL 117.76 mL
1 mM 2.36 mL 11.78 mL 23.55 mL
2 mM 1.18 mL 5.89 mL 11.78 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

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References are publications that support the biological activity of the product.

Sun et al (2017) The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 10 eaai8583 PMID: 28420758

If you know of a relevant reference for RCM 1, please let us know.

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