Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: FOXM1 inhibitor
Chemical Name: 2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile
Purity: ≥98% (HPLC)

Biological Activity for RCM 1

RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.

Technical Data for RCM 1

M. Wt 424.58
Formula C20H12N2OS4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 339163-65-4
PubChem ID 4273985
Smiles O=C(C1=CC=CS1)CSC2=C(C(C3=CC=CS3)=CC(C4=CC=CS4)=N2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RCM 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.49 20

Preparing Stock Solutions for RCM 1

The following data is based on the product molecular weight 424.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.78 mL 58.88 mL 117.76 mL
1 mM 2.36 mL 11.78 mL 23.55 mL
2 mM 1.18 mL 5.89 mL 11.78 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for RCM 1

References are publications that support the biological activity of the product.

Sun et al (2017) The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 10 eaai8583 PMID: 28420758

If you know of a relevant reference for RCM 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Transcription Factor Inhibitors

Keywords: RCM 1, RCM 1 supplier, RCM1, forkhead, box, m1, FOXM1, transcription, factor, inhibitors, inhibits, allergy, cytokine, production, goblet, cells, anti-inflammatory, anti-asthma, Other, Transcription, Factors, 6845, Tocris Bioscience

Citations for RCM 1

Citations are publications that use Tocris products.

Currently there are no citations for RCM 1. Do you know of a great paper that uses RCM 1 from Tocris? Please let us know.

Reviews for RCM 1

There are currently no reviews for this product. Be the first to review RCM 1 and earn rewards!

Have you used RCM 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review