RC 160

Discontinued Product

RC 160 (Cat. No. 3139) has been withdrawn from sale for commercial reasons.
Description: sst analog
Alternative Names: Vapreotide

Biological Activity for RC 160

RC 160 is a cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.

Technical Data for RC 160

M. Wt 1131.37
Formula C57H70N12O9S2

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7)

Storage Desiccate at -20°C
CAS Number 103222-11-3
PubChem ID 6918026
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RC 160

Certificate of Analysis / Product Datasheet
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References for RC 160

References are publications that support the biological activity of the product.

Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on GH, Ins and glucagon release. Life Sci. 41 1011 PMID: 2886886

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476

Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607

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Keywords: RC 160, RC 160 supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, 3139, Tocris Bioscience

Citations for RC 160

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Currently there are no citations for RC 160.

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