RC 160

Pricing Availability   Qty
Cat.No. 3139 - RC 160 | D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: 2 - 7) | CAS No. 103222-11-3
Description: sst analog
Alternative Names: Vapreotide
Datasheet
Citations
Reviews
Literature

Biological Activity

Cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.

Technical Data

M. Wt 1131.37
Formula C57H70N12O9S2
Sequence FCYWKVCW

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7)

Storage Desiccate at -20°C
CAS Number 103222-11-3
PubChem ID 6918026
InChI Key SWXOGPJRIDTIRL-DOUNNPEJSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 0.20 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on GH, Ins and glucagon release. Life Sci. 41 1011 PMID: 2886886

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476

Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607


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Keywords: RC 160, RC 160 supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, 3139, Tocris Bioscience

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