(R,R)-THC

Pricing Availability   Qty
Description: Potent subtype-selective ligand; ERα agonist/ERβ antagonist
Chemical Name: (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Pathways (1)

Biological Activity for (R,R)-THC

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).

Technical Data for (R,R)-THC

M. Wt 320.42
Formula C22H24O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 138090-06-9
PubChem ID 446849
InChI Key MASYAWHPJCQLSW-ZIAGYGMSSA-N
Smiles OC3=CC=C(C(C[C@H]4CC)=C3)C2=C4C1=CC=C(O)C=C1C[C@H]2CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R,R)-THC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.04 100
ethanol 32.04 100

Preparing Stock Solutions for (R,R)-THC

The following data is based on the product molecular weight 320.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.6 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Reconstitution Calculator

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Product Datasheets for (R,R)-THC

Certificate of Analysis / Product Datasheet
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View Related Products by Target

Keywords: (R,R)-THC, (R,R)-THC supplier, Potent, subtype, selective, ligands, Erα, Eralpha, agonists, ERβ, ERbeta, antagonists, ER, ERR, Estrogen, Receptors, and, Related, 1990, Tocris Bioscience

8 Citations for (R,R)-THC

Citations are publications that use Tocris products. Selected citations for (R,R)-THC include:

Simpkins et al (2012) Src Inhibition with saracatinib reverses fulves. resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res 18 5911 PMID: 22896656

Xing et al (2012) Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β. PLoS One 7 e36890 PMID: 22723832

Nicholson et al (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. PLoS One 193 722 PMID: 25167991

Wang et al (2015) Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther 9 3755 PMID: 26229438


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Pathways for (R,R)-THC

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.