Pricing Availability   Qty
Description: Potent subtype-selective ligand; ERα agonist/ERβ antagonist
Chemical Name: (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Purity: ≥98% (HPLC)
Citations (8)
Literature (1)
Pathways (1)

Biological Activity for (R,R)-THC

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).

Technical Data for (R,R)-THC

M. Wt 320.42
Formula C22H24O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 138090-06-9
PubChem ID 446849
Smiles OC3=CC=C(C(C[C@H]4CC)=C3)C2=C4C1=CC=C(O)C=C1C[C@H]2CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R,R)-THC

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.04 100
ethanol 32.04 100

Preparing Stock Solutions for (R,R)-THC

The following data is based on the product molecular weight 320.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.6 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for (R,R)-THC

Certificate of Analysis / Product Datasheet
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Keywords: (R,R)-THC, (R,R)-THC supplier, Potent, subtype, selective, ligands, Erα, Eralpha, agonists, ERβ, ERbeta, antagonists, ER, ERR, Estrogen, Receptors, and, Related, 1990, Tocris Bioscience

8 Citations for (R,R)-THC

Citations are publications that use Tocris products. Selected citations for (R,R)-THC include:

Nicholson et al (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. PLoS One 193 722 PMID: 25167991

Wang et al (2015) Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther 9 3755 PMID: 26229438

Guo et al (2011) Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. J Biol Chem 286 27882 PMID: 21652696

Vona et al (2019) Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling? Cell Physiol Biochem 53 186 PMID: 31278696

Do you know of a great paper that uses (R,R)-THC from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for (R,R)-THC

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.