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(R)-(+)-Etomoxir sodium salt
Inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||6.41||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 320.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.59 mL||77.94 mL||155.89 mL|
|1 mM||3.12 mL||15.59 mL||31.18 mL|
|2 mM||1.56 mL||7.79 mL||15.59 mL|
|10 mM||0.31 mL||1.56 mL||3.12 mL|
References are publications that support the biological activity of the product.
Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 44 415 PMID: 12576524
Agius et al (1991) Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 42 1717 PMID: 1930298
Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 6 2349 PMID: 1531968
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Keywords: (R)-(+)-Etomoxir sodium salt, (R)-(+)-Etomoxir sodium salt supplier, carnitine, o-palmitoyltransferase, acyltransferases, I, CPT1, inhibitors, inhibits, Other, Transferases, 4539, Tocris Bioscience
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Reviews for (R)-(+)-Etomoxir sodium salt
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MCF7 cells were pretreated with or without 25, 50 μmol/L Etomoxir for 24 h.
Product was diluted to 20 uM in tissue culture and various cancer cells were treated for 18-30 h at this concentration. Enzyme activity was measured by flow cytometry after. Results were strongly replicable.
Etomoxir shows good solubility profile when diluted from 20 mM stock in DMSO. Does not cause cell death across cell lines at 20 uM.
Exogenous application on acute brain slices
Pre-incubation of 15 minutes at 100 uM
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