(R)-(+)-Etomoxir sodium salt

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Description: Carnitine palmitoyltransferase I (CPT1) inhibitor
Chemical Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Reviews (3)

Biological Activity for (R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data for (R)-(+)-Etomoxir sodium salt

M. Wt 320.74
Formula C15H18ClNaO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 828934-41-4
PubChem ID 57345784
Smiles [Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(+)-Etomoxir sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 6.41 20
DMSO 6.41 20 with gentle warming

Preparing Stock Solutions for (R)-(+)-Etomoxir sodium salt

The following data is based on the product molecular weight 320.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.59 mL 77.94 mL 155.89 mL
1 mM 3.12 mL 15.59 mL 31.18 mL
2 mM 1.56 mL 7.79 mL 15.59 mL
10 mM 0.31 mL 1.56 mL 3.12 mL

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Product Datasheets for (R)-(+)-Etomoxir sodium salt

Certificate of Analysis / Product Datasheet
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References for (R)-(+)-Etomoxir sodium salt

References are publications that support the biological activity of the product.

Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 44 415 PMID: 12576524

Agius et al (1991) Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 42 1717 PMID: 1930298

Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 6 2349 PMID: 1531968

If you know of a relevant reference for (R)-(+)-Etomoxir sodium salt, please let us know.

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Keywords: (R)-(+)-Etomoxir sodium salt, (R)-(+)-Etomoxir sodium salt supplier, carnitine, o-palmitoyltransferase, acyltransferases, I, CPT1, inhibitors, inhibits, Other, Transferases, 4539, Tocris Bioscience

Citations for (R)-(+)-Etomoxir sodium salt

Citations are publications that use Tocris products.

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Reviews for (R)-(+)-Etomoxir sodium salt

Average Rating: 5 (Based on 3 Reviews.)

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Very effective for CPT-1 inhibiton.
By Anonymous on 03/27/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF7

MCF7 cells were pretreated with or without 25, 50 μmol/L Etomoxir for 24 h.

review image

Efficiently blocks FA catabolism in cell culture.
By Anonymous on 01/27/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: 293T

Product was diluted to 20 uM in tissue culture and various cancer cells were treated for 18-30 h at this concentration. Enzyme activity was measured by flow cytometry after. Results were strongly replicable.

Etomoxir shows good solubility profile when diluted from 20 mM stock in DMSO. Does not cause cell death across cell lines at 20 uM.

review image

CPT1 inhibition.
By Anonymous on 01/04/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Exogenous application on acute brain slices

Pre-incubation of 15 minutes at 100 uM