(R)-(+)-Etomoxir sodium salt

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Cat.No. 4539 - (R)-(+)-Etomoxir sodium salt | C15H18ClNaO4 | CAS No. 828934-41-4
Description: Carnitine palmitoyltransferase I (CPT1) inhibitor
Chemical Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (2)
Literature

Biological Activity

Inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data

M. Wt 320.74
Formula C15H18ClNaO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 828934-41-4
PubChem ID 57345784
InChI Key RPACBEVZENYWOL-XFULWGLBSA-M
Smiles [Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.41 20
DMSO 6.41 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 320.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.59 mL 77.94 mL 155.89 mL
1 mM 3.12 mL 15.59 mL 31.18 mL
2 mM 1.56 mL 7.79 mL 15.59 mL
10 mM 0.31 mL 1.56 mL 3.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 44 415 PMID: 12576524

Agius et al (1991) Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 42 1717 PMID: 1930298

Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 6 2349 PMID: 1531968


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Keywords: (R)-(+)-Etomoxir sodium salt, (R)-(+)-Etomoxir sodium salt supplier, carnitine, o-palmitoyltransferase, acyltransferases, I, CPT1, inhibitors, inhibits, Other, Transferases, 4539, Tocris Bioscience

Citations for (R)-(+)-Etomoxir sodium salt

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Currently there are no citations for (R)-(+)-Etomoxir sodium salt. Do you know of a great paper that uses (R)-(+)-Etomoxir sodium salt from Tocris? Please let us know.

Reviews for (R)-(+)-Etomoxir sodium salt

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etomoxir was used as a CPT1 inhibitor
By Anonymous on 10/05/2018
Assay Type: In Vitro
Species: Human

Etomoxir was used as a CPT1 inhibitor in endothelial cells. The data was shown in the publication PubMed ID 29429925.

PMID: 29429925

CPT1 inhibition
By Anonymous on 01/04/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Exogenous application on acute brain slices

Pre-incubation of 15 minutes at 100 uM


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