(R)-DPN

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Cat.No. 4494 - (R)-DPN | C15H13NO2 | CAS No. 524047-78-7
Description: Enantiomer of DPN (Cat. No. 1494)
Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).

Technical Data

M. Wt 239.27
Formula C15H13NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 524047-78-7
PubChem ID 6604873
InChI Key GHZHWDWADLAOIQ-ZDUSSCGKSA-N
Smiles OC(C=C2)=CC=C2C[C@@H](C#N)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.93 100
ethanol 23.93 100
1eq. NaOH 5.98 25

Preparing Stock Solutions

The following data is based on the product molecular weight 239.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.79 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817 PMID: 19074580

Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528 PMID: 22122563


If you know of a relevant reference for (R)-DPN, please let us know.

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View all Estrogen and Related Receptor Agonists

Keywords: (R)-DPN, supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience

1 Citation for (R)-DPN

Citations are publications that use Tocris products. Selected citations for (R)-DPN include:

Murata et al (2014) Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55 PMID: 24334513


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for (R)-DPN

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.