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Cat.No. 4494 - (R)-DPN | C15H13NO2 | CAS No. 524047-78-7
Description: Enantiomer of DPN (Cat. No. 1494)
Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)
Pathways (1)

Biological Activity for (R)-DPN

(R)-DPN is an enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).

Compound Libraries for (R)-DPN

(R)-DPN is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (R)-DPN

M. Wt 239.27
Formula C15H13NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 524047-78-7
PubChem ID 6604873
Smiles OC(C=C2)=CC=C2C[C@@H](C#N)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-DPN

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 5.98 25
DMSO 23.93 100
ethanol 23.93 100

Preparing Stock Solutions for (R)-DPN

The following data is based on the product molecular weight 239.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.79 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References for (R)-DPN

References are publications that support the biological activity of the product.

Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817 PMID: 19074580

Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528 PMID: 22122563

If you know of a relevant reference for (R)-DPN, please let us know.

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Keywords: (R)-DPN, (R)-DPN supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Estrogen, and, Related, Receptors, 4494, Tocris Bioscience

1 Citation for (R)-DPN

Citations are publications that use Tocris products. Selected citations for (R)-DPN include:

Murata et al (2014) Rat uterine oxyt. receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55 PMID: 24334513

Do you know of a great paper that uses (R)-DPN from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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Pathways for (R)-DPN


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.