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Submit Review(R)-DPN is an enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).
M. Wt | 239.27 |
Formula | C15H13NO2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 524047-78-7 |
PubChem ID | 6604873 |
InChI Key | GHZHWDWADLAOIQ-ZDUSSCGKSA-N |
Smiles | OC(C=C2)=CC=C2C[C@@H](C#N)C1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817 PMID: 19074580
Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528 PMID: 22122563
Keywords: (R)-DPN, (R)-DPN supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Estrogen, and, Related, Receptors, 4494, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for (R)-DPN include:
Murata et al (2014) Rat uterine oxyt. receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55 PMID: 24334513
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