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(R)-DPN

Cat. No. 4494 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 4494 - (R)-DPN | C15H13NO2 | CAS No. 524047-78-7
Description: Enantiomer of DPN (Cat. No. 1494)
Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).

Technical Data

M. Wt 239.27
Formula C15H13NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 524047-78-7
PubChem ID 6604873
InChI Key GHZHWDWADLAOIQ-ZDUSSCGKSA-N
Smiles OC(C=C2)=CC=C2C[C@@H](C#N)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 5.98 25
DMSO 23.93 100
ethanol 23.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 239.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.79 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817 PMID: 19074580

Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528 PMID: 22122563

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Keywords: (R)-DPN, (R)-DPN supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Estrogen, and, Related, Receptors, 4494, Tocris Bioscience

1 Citation for (R)-DPN

Citations are publications that use Tocris products. Selected citations for (R)-DPN include:

Murata et al (2014) Rat uterine oxyt. receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55 PMID: 24334513

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Literature in this Area

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Pathways for (R)-DPN

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.