Q94 hydrochloride

Discontinued Product

Q94 hydrochloride (Cat. No. 4755) has been withdrawn from sale for commercial reasons.
Cat.No. 4755 - Q94 hydrochloride | C21H17ClN2.HCl | CAS No. 1052076-77-3
Description: Negative allosteric modulator at PAR1 receptor
Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Q94 hydrochloride

PAR1 negative allosteric modulator (IC50 = 916 nM); inhibits PAR1-Gαq interaction. Selective for PAR1 over PAR2. Blocks thrombin-induced intracellular calcium mobilization (IC50 = 10.3 nM), CCL2 expression, ERK1/2 and MLC phosphorylation, and IP3 production in cells.

Technical Data for Q94 hydrochloride

M. Wt 369.29
Formula C21H17ClN2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1052076-77-3
PubChem ID 16258217
InChI Key WXIWQTVPWYFEHP-UHFFFAOYSA-N
Smiles ClC(C=C4)=CC=C4CN2C1=CC=CC=C1N=C2CC3=CC=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Q94 hydrochloride

References for Q94 hydrochloride

References are publications that support the biological activity of the product.

Deng et al (2008) Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol.Biol.Cell 19 2520 PMID: 18353977

Asteriti et al (2012) Modulation of PAR1 signalling by benzimidazole compounds. Br.J.Pharmacol. 167 80 PMID: 22519452

Scotton et al (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J.Clin.Invest. 119 2550 PMID: 19652365

View Related Products by Target

View Related Products by Product Action

View all Protease-Activated Receptor Modulators

Keywords: Q94 hydrochloride, Q94 hydrochloride supplier, PAR1, protease, activated, receptors, negative, allosteric, modulators, selective, blocks, thrombin, induced, calcium, mobilization, NAM, Protease-Activated, Receptors, 4755, Tocris Bioscience

Citations for Q94 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Q94 hydrochloride.

Reviews for Q94 hydrochloride

There are currently no reviews for this product. Be the first to review Q94 hydrochloride and earn rewards!

Have you used Q94 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.