Q94 hydrochloride

Discontinued Product

Q94 hydrochloride (Cat. No. 4755) has been withdrawn from sale for commercial reasons.
Description: Negative allosteric modulator at PAR1 receptor
Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)

Biological Activity for Q94 hydrochloride

PAR1 negative allosteric modulator (IC50 = 916 nM); inhibits PAR1-Gαq interaction. Selective for PAR1 over PAR2. Blocks thrombin-induced intracellular calcium mobilization (IC50 = 10.3 nM), CCL2 expression, ERK1/2 and MLC phosphorylation, and IP3 production in cells.

Technical Data for Q94 hydrochloride

M. Wt 369.29
Formula C21H17ClN2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1052076-77-3
PubChem ID 16258217
Smiles ClC(C=C4)=CC=C4CN2C1=CC=CC=C1N=C2CC3=CC=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Q94 hydrochloride

References for Q94 hydrochloride

References are publications that support the biological activity of the product.

Deng et al (2008) Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol.Biol.Cell 19 2520 PMID: 18353977

Asteriti et al (2012) Modulation of PAR1 signalling by benzimidazole compounds. Br.J.Pharmacol. 167 80 PMID: 22519452

Scotton et al (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J.Clin.Invest. 119 2550 PMID: 19652365

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Citations for Q94 hydrochloride

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Currently there are no citations for Q94 hydrochloride.

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