You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductQ94 hydrochloride (Cat. No. 4755) has been withdrawn from sale for commercial reasons.
Biological Activity for Q94 hydrochloride
PAR1 negative allosteric modulator (IC50 = 916 nM); inhibits PAR1-Gαq interaction. Selective for PAR1 over PAR2. Blocks thrombin-induced intracellular calcium mobilization (IC50 = 10.3 nM), CCL2 expression, ERK1/2 and MLC phosphorylation, and IP3 production in cells.
Technical Data for Q94 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Q94 hydrochloride
References for Q94 hydrochloride
References are publications that support the biological activity of the product.
Deng et al (2008) Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol.Biol.Cell 19 2520 PMID: 18353977
Asteriti et al (2012) Modulation of PAR1 signalling by benzimidazole compounds. Br.J.Pharmacol. 167 80 PMID: 22519452
Scotton et al (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J.Clin.Invest. 119 2550 PMID: 19652365
View Related Products by Product Action
Keywords: Q94 hydrochloride, Q94 hydrochloride supplier, PAR1, protease, activated, receptors, negative, allosteric, modulators, selective, blocks, thrombin, induced, calcium, mobilization, NAM, Protease-Activated, Receptors, 4755, Tocris Bioscience
Citations for Q94 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Q94 hydrochloride.
Reviews for Q94 hydrochloride
There are currently no reviews for this product. Be the first to review Q94 hydrochloride and earn rewards!
Have you used Q94 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.