PSEM 89S

Pricing Availability Delivery Time Qty
Cat.No. 6426 - PSEM 89S | C16H22N2O3.CF3CO2H | CAS No. 1336913-03-1
Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Chemical Name: N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

PSAM (pharmacologically selective actuator module) agonist. Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Technical Data

M. Wt 404.38
Formula C16H22N2O3.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1336913-03-1
Smiles OC(C(F)(F)F)=O.O=C(N[C@@H]1CN2CCC1CC2)C(C=C3OC)=C(C=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.44 100
ethanol 40.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Magnus et al (2011) Chemical and genetic engineering of selective ion channel-ligand interactions. Science 333 1292 PMID: 21885782

Cerritelli et al (2016) Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 11 e0153187 PMID: 27077912


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Literature in this Area

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