PSEM 308 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 6425 - PSEM 308 hydrochloride | C17H21N3.HCl
Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Chemical Name: 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.

Recommended concentration for use in mice is 5 mg/kg or lower

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Technical Data

M. Wt 303.83
Formula C17H21N3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles CC1CC2=CC=CC3=C2N1N=C4C(C3)[N@@]5CC[C@H]4CC5.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.08 20
ethanol 6.08 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 303.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.91 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID: 22246433

Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID: 26924434

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID: 22801496

Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID: 29027903


If you know of a relevant reference for PSEM 308 hydrochloride, please let us know.

View Related Products by Target

Keywords: PSEM 308 hydrochloride, PSEM 308 hydrochloride supplier, PSEM308, HCl, PSAM, L141F-GlyR, chimeric, channel, pharmacologically, selective, actuator, molecule, agonists, agonism, activates, activators, L141F,Y115F-5HT3, effector, modules, Glycine, Receptors, 5-HT3, PSEMs, 6425, Tocris Bioscience

Citations for PSEM 308 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for PSEM 308 hydrochloride. Do you know of a great paper that uses PSEM 308 hydrochloride from Tocris? Please let us know.

Reviews for PSEM 308 hydrochloride

There are currently no reviews for this product. Be the first to review PSEM 308 hydrochloride and earn rewards!

Have you used PSEM 308 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Chemogenetics

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.