You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PSEM 308 hydrochloride
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.
Recommended concentration for use in mice is 5 mg/kg or lower.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||6.08||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 303.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||16.46 mL||82.28 mL||164.57 mL|
|1 mM||3.29 mL||16.46 mL||32.91 mL|
|2 mM||1.65 mL||8.23 mL||16.46 mL|
|10 mM||0.33 mL||1.65 mL||3.29 mL|
References are publications that support the biological activity of the product.
Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID: 22246433
Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID: 26924434
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID: 22801496
Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID: 29027903
If you know of a relevant reference for PSEM 308 hydrochloride, please let us know.
Keywords: PSEM 308 hydrochloride, PSEM 308 hydrochloride supplier, PSEM308, HCl, PSAM, L141F-GlyR, chimeric, channel, pharmacologically, selective, actuator, molecule, agonists, agonism, activates, activators, L141F,Y115F-5HT3, effector, modules, Glycine, Receptors, 5-HT3, PSEMs, 6425, Tocris Bioscience
Citations for PSEM 308 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for PSEM 308 hydrochloride. Do you know of a great paper that uses PSEM 308 hydrochloride from Tocris? Please let us know.
Reviews for PSEM 308 hydrochloride
There are currently no reviews for this product. Be the first to review PSEM 308 hydrochloride and earn rewards!
Have you used PSEM 308 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.