PPPA

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Cat.No. 2274 - PPPA | C9H18NO5P | CAS No. 113190-92-4
Description: Competitive NR2A antagonist
Alternative Names: LY 257883
Chemical Name: (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid
Datasheet
Citations (1)
Literature

Biological Activity

Competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively).

Technical Data

M. Wt 251.22
Formula C9H18NO5P
Storage Desiccate at RT
CAS Number 113190-92-4
PubChem ID 90488757
InChI Key GPFGYOMXVORLFH-RXZNUWRWSA-N
Smiles O=P(CCC[C@@H]1C[C@H]([C@](O)=O)NCC1)(O)O.O=C([C@H]2NCC[C@@H](CCCP(O)(O)=O)C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 251.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.9 mL 39.81 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Benveniste and Mayer (1992) Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists. Mol.Pharmacol. 42 679 PMID: 1435743

Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167

Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066 PMID: 15743930


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Keywords: PPPA, supplier, Competitive, NR2A, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY257883, LY, 257883, NMDA, Receptors, Tocris Bioscience

1 Citation for PPPA

Citations are publications that use Tocris products. Selected citations for PPPA include:

Liu et al (2015) The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain 8 49 PMID: 26282667


Do you know of a great paper that uses PPPA from Tocris? If so please let us know.

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Pathways for PPPA

Protocols

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