You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for PMX 464
PMX 464 is a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
Technical Data for PMX 464
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PMX 464
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PMX 464
The following data is based on the product molecular weight 243.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.11 mL||20.55 mL||41.1 mL|
|5 mM||0.82 mL||4.11 mL||8.22 mL|
|10 mM||0.41 mL||2.06 mL||4.11 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References for PMX 464
References are publications that support the biological activity of the product.
Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167 PMID: 17572693
Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661 PMID: 18587424
Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350 PMID: 15655539
If you know of a relevant reference for PMX 464, please let us know.
View Related Products by Product Action
Keywords: PMX 464, PMX 464 supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Thioredoxin, Reductases, 4996, Tocris Bioscience
1 Citation for PMX 464
Citations are publications that use Tocris products. Selected citations for PMX 464 include:
Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168 PMID: 28233787
Do you know of a great paper that uses PMX 464 from Tocris? Please let us know.
Reviews for PMX 464
There are currently no reviews for this product. Be the first to review PMX 464 and earn rewards!
Have you used PMX 464?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.