PMX 464

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Cat.No. 4996 - PMX 464 | C13H9NO2S | CAS No. 485842-97-5
Description: Putative inhibitor of the Trx-TrxR system; antiproliferative
Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.

Technical Data

M. Wt 243.28
Formula C13H9NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 485842-97-5
PubChem ID 482697
InChI Key SDYBYKXWYDVVKP-UHFFFAOYSA-N
Smiles O=C(C=C3)C=CC3(O)C2=NC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.33 100
ethanol 24.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 243.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.55 mL 41.1 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.06 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167 PMID: 17572693

Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661 PMID: 18587424

Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350 PMID: 15655539


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Keywords: PMX464 PMX_464 antiproliferative thioredoxin reductase TrxR Trx1 inhibitors inhibits cell proliferation TrxR

1 Citation for PMX 464

Citations are publications that use Tocris products. Selected citations for PMX 464 include:

Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168 PMID: 28233787


Do you know of a great paper that uses PMX 464 from Tocris? If so please let us know.

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